The complement system resembles a double-edged sword since its activation can either
benefit or harm the host. Thus, regulation of this system is of utmost importance and …

Background Recent investigations of the meninges have highlighted the importance of the
dura layer in central nervous system immune surveillance beyond a purely structural role …

Recent studies have reported that complement-related proteins modulate brain
development through regulating synapse processes in the cortex. CSMD3 belongs to a …

Estrogen action is mediated by various genes, including estrogen-responsive genes
(ERGs). ERGs have been used as reporter-genes and markers for gene expression. Gene …

The acidic pH of the tumor microenvironment plays a critical role in driving cancer
development toward a more aggressive phenotype, but the underlying mechanisms are …

Inguinal hernia develops primarily in elderly men, and more than one in four men will
undergo inguinal hernia repair during their lifetime. However, the underlying mechanisms …

Lung adenocarcinoma (LUAD) is the most common histological subtype of non-small cell
lung cancer, but novel biomarkers for early diagnosis are lacking. Extensive effort has been …

Background The prediction of breast cancer intrinsic subtypes has been introduced as a
valuable strategy to determine patient diagnosis and prognosis, and therapy response. The …

Purpose: Breast cancer is among the leading causes of cancer-related death; discovery of
novel prognostic markers is needed to improve outcomes. Combining systems biology and …

Aromatase inhibitors (AIs) are the most effective endocrine treatment for estrogen receptor α-
positive (ERα+) postmenopausal breast cancer. Identification of biomarkers that are able to …