Abstract tRNAscan-SE has been widely used for transfer RNA (tRNA) gene prediction for
over twenty years, developed just as the first genomes were decoded. With the massive …

Highlights•Quiescence is associated with differentiation in Leishmania spp.•RNA and
protein reprogramming is necessary for differentiation in Leishmania spp.•RNA and protein …

Leishmania parasites cause a broad spectrum of clinical disease. Here we report the
sequencing of the genomes of two species of Leishmania: Leishmania infantum and …

The use of oxygen as the final electron acceptor in aerobic organisms results in an
improvement in the energy metabolism. However, as a byproduct of the aerobic metabolism …

We report new organoselenium compounds bearing the sulfonamide moiety as effective
inhibitors of the β-isoform of Carbonic Anhydrase from the unicellular parasitic protozoan L …

Selenoproteins are proteins that incorporate selenocysteine (Sec), a nonstandard amino
acid encoded by UGA, normally a stop codon. Sec synthesis requires the enzyme …

Mitochondrial tRNA import is widespread in eukaryotes. Yet, the mechanism that determines
its specificity is unknown. Previous in vivo experiments using the tRNAsMet, tRNAIle and …

The in vitro leishmanicidal activities of a series of 48 recently synthesized selenium
derivatives against Leishmania infantum and Leishmania braziliensis parasites were tested …

The generation of new antileishmanial drugs has become a priority. Selenium and its
derivatives stand out as having promising leishmanicidal activity. In fact, some parasites …

Renal fibrosis is the final result of the progression of chronic kidney disease (CKD) to end-
stage renal disease (ESRD). Earlier studies confirmed that selenium (Se) displays a close …