Genomic DNA is folded into loops and topologically associating domains (TADs), which
serve important structural and regulatory roles. It has been proposed that these genomic …

SMC (structural maintenance of chromosomes) complexes—which include condensin,
cohesin and the SMC5–SMC6 complex—are major components of chromosomes in all …

The eukaryotic genome is organized within cells as chromatin. For proper information
output, higher-order chromatin structures can be regulated dynamically. How such structures …

Condensins are large protein complexes that play a central role in chromosome
organization and segregation in the three domains of life. They display highly characteristic …

Condensin plays crucial roles in chromosome organization and compaction, but the
mechanistic basis for its functions remains obscure. We used single-molecule imaging to …

The mechanism by which chromatids and chromosomes are segregated during mitosis and
meiosis is a major puzzle of biology and biophysics. Using polymer simulations of …

Structural maintenance of chromosome (SMC) complexes are proteinaceous rings that
embrace DNA to enable vital chromosomal functions. The ring is formed by two SMC …

The cohesin complex topologically encircles DNA to promote sister chromatid cohesion.
Alternatively, cohesin extrudes DNA loops, thought to reflect chromatin domain formation …

Condensin is a structural maintenance of chromosomes (SMC) complex family member
thought to build mitotic chromosomes by DNA loop extrusion. However, condensin variants …

The ring-shaped cohesin complex topologically entraps two DNA molecules to establish
sister chromatid cohesion. Cohesin also shapes the interphase chromatin landscape with …