The roles of macrophages and microglia in multiple sclerosis and experimental autoimmune encephalomyelitis

F Chu, M Shi, C Zheng, D Shen, J Zhu, X Zheng… - Journal of …, 2018 - Elsevier
Multiple sclerosis (MS) is an autoimmune and neurodegenerative disorder characterized by
chronic inflammation, demyelination, as well as axonal and neuronal loss in the central …

Gut microbiota in multiple sclerosis and experimental autoimmune encephalomyelitis: current applications and future perspectives

F Chu, M Shi, Y Lang, D Shen, T Jin… - Mediators of …, 2018 - Wiley Online Library
The gut environment and gut microbiome dysbiosis have been demonstrated to significantly
influence a range of disorders in humans, including obesity, diabetes, rheumatoid arthritis …

Epidemiology of multiple sclerosis

E Leray, T Moreau, A Fromont, G Edan - Revue neurologique, 2016 - Elsevier
Multiple sclerosis (MS) is the most frequently seen demyelinating disease, with a prevalence
that varies considerably, from high levels in North America and Europe (> 100/100,000 …

Latitude continues to be significantly associated with the prevalence of multiple sclerosis: an updated meta-analysis

S Simpson, W Wang, P Otahal, L Blizzard… - Journal of Neurology …, 2019 - jnnp.bmj.com
Objectives Previous studies have demonstrated a strong latitudinal gradient in multiple
sclerosis (MS) prevalence. Herein, we present a meta-analysis of the latitudinal gradient of …

The multiple sclerosis (MS) genetic risk factors indicate both acquired and innate immune cell subsets contribute to MS pathogenesis and identify novel therapeutic …

GP Parnell, DR Booth - Frontiers in immunology, 2017 - frontiersin.org
Multiple sclerosis (MS) is known to be a partially heritable autoimmune disease. The risk of
developing MS increases from typically 1 in 1,000 in the normal population to 1 in 4 or so for …

Temporal trends in multiple sclerosis prevalence and incidence in a large population

DL Rotstein, H Chen, AS Wilton, JC Kwong, RA Marrie… - Neurology, 2018 - AAN Enterprises
Objective We sought to better understand the reasons for increasing prevalence of multiple
sclerosis (MS) by studying prevalence in relation to incidence, mortality rates, sex ratio, and …

Anatomical distribution of cuprizone-induced lesions in C57BL6 mice

J Goldberg, T Clarner, C Beyer, M Kipp - Journal of Molecular …, 2015 - Springer
Although multiple sclerosis (MS) has been considered a white matter disease, MS lesions
occur frequently in the gray matter parts of the brain. Gray matter demyelination and atrophy …

Change in multiple sclerosis prevalence over time in Australia 2010–2017 utilising disease-modifying therapy prescription data

JA Campbell, S Simpson Jr, H Ahmad… - Multiple Sclerosis …, 2020 - journals.sagepub.com
Objective: Determine the prevalence of multiple sclerosis (MS) in Australia in 2017 using MS-
specific disease-modifying therapy (DMT) prescription data and estimate the change in …

Immunoregulatory effects of tolerogenic probiotics in multiple sclerosis

H Atabati, E Yazdanpanah, H Mortazavi… - Reviews on New Drug …, 2021 - Springer
Gut microbiota has essential roles in the prevention and progression of multiple sclerosis
(MS). The association between the gut microbiota and the central nervous system (CNS) or …

Sun exposure across the life course significantly modulates early multiple sclerosis clinical course

S Simpson Jr, I Van der Mei, RM Lucas… - Frontiers in …, 2018 - frontiersin.org
Background Low vitamin D and/or sun exposure have been associated with increased risk
of multiple sclerosis (MS) onset. However, comparatively, few studies have prospectively …