The trabecular meshwork (TM) is located in the anterior segment of the eye and is
responsible for regulating the outflow of aqueous humor. Increased resistance to aqueous …

For many retinal diseases, including age-related macular degeneration (AMD), glaucoma,
and diabetic retinopathy (DR), the exact pathogenesis is still unclear. Moreover, the currently …

Evidence-based update of the Cataract in the Adult Eye Preferred Practice Pattern®(PPP)
guidelines, describing the prevalence, risk factors, and natural history of cataract …

Primary Open-Angle Glaucoma | New England Journal of Medicine Skip to main content The
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Glaucoma is a leading cause of irreversible blindness worldwide. Primary open-angle
glaucoma (POAG), the most common type, is a complex inherited disorder that is …

Glaucoma is a heterogeneous group of disorders that progressively lead to blindness due to
loss of retinal ganglion cells and damage to the optic nerve. It is a leading cause of …

A substantial fraction of glaucoma has a genetic basis. About 5% of primary open angle
glaucoma (POAG) is currently attributed to single-gene or Mendelian forms of glaucoma (ie …

Mutations in myocilin (MYOC) are the most common genetic cause of primary open angle
glaucoma (POAG), but the mechanisms underlying MYOC-associated glaucoma are not fully …

The most critical risk factor for optic nerve damage in cases of primary open-angle glaucoma
(POAG) is an increased intraocular pressure (IOP) caused by a resistance to aqueous …

Primary open angle glaucoma (POAG) is a complex progressive optic nerve neuropathy
triggered by both environmental and genetic risk factors. Several ocular tissues, including …