Epidermal growth factor receptor inhibitors as potential anticancer agents: An update of recent progress
Epidermal growth factor receptor (EGFR) is a vital intermediate in cell signaling pathway
including cell proliferation, angiogenesis, apoptosis, and metastatic spread and also having …
including cell proliferation, angiogenesis, apoptosis, and metastatic spread and also having …
An insight into the medicinal perspective of synthetic analogs of imidazole
Imidazole remains a privileged heterocycle in drug discovery. Imidazole scaffold is a
ubiquitous motif that is present in several pharmacologically important drug molecules such …
ubiquitous motif that is present in several pharmacologically important drug molecules such …
In-vitro anticancer evaluation of newly designed and characterized tri/tetra-substituted imidazole congeners-maternal embryonic leucine zipper kinase inhibitors …
M Mahapatra, P Mohapatra, K Pakeeraiah… - International Journal of …, 2023 - Elsevier
Our cascading attempt to develop new potent molecules now involves designing a series of
imidazole derivatives and synthesizing two sets of 2, 4, 5-tri-substituted (4a–4d) and 1, 2, 4 …
imidazole derivatives and synthesizing two sets of 2, 4, 5-tri-substituted (4a–4d) and 1, 2, 4 …
Design, synthesis and biological evaluation of a new series of thiazolyl-pyrazolines as dual EGFR and HER2 inhibitors
Epidermal growth factor receptor (EGFR, also known as HER1) and HER2, prominent
members of receptor tyrosine kinase (RTK) superfamily, have been reported as diagnostic or …
members of receptor tyrosine kinase (RTK) superfamily, have been reported as diagnostic or …
Curcumin based pyrazole-thiazole hybrids as antiproliferative agents: Synthesis, pharmacokinetic, photophysical properties, and docking studies
A series of new curcumin pyrazole-thiazole hybrids (C 1-C 8) were synthesized and
characterized by fundamental spectral analysis. The synthesized compounds were tested for …
characterized by fundamental spectral analysis. The synthesized compounds were tested for …
Anticancer activities of tetrasubstituted imidazole‐pyrimidine‐sulfonamide hybrids as inhibitors of EGFR Mutants
EM Alghamdi, ZM Alamshany, MA El Hamd… - …, 2023 - Wiley Online Library
A new series of tetrasubstituted imidazole derivatives carrying pyrimidine sulfonamide
pharmacophores has been synthesized and evaluated for their anticancer activities. In‐vitro …
pharmacophores has been synthesized and evaluated for their anticancer activities. In‐vitro …
An insight into recent developments in imidazole based heterocyclic compounds as anticancer agents: Synthesis, SARs, and mechanism of actions
Among all non-communicable diseases, cancer is ranked as the second most common
cause of death and is rising constantly. While cancer treatments mainly include radiation …
cause of death and is rising constantly. While cancer treatments mainly include radiation …
Exploring the molecular insights of imidazole and benzimidazole scaffold for cancer therapy: Synthesis, in-vitro cytotoxicity and SAR studies
A Ghara, GSP Matada, P Pramanick… - Journal of Molecular …, 2024 - Elsevier
Significant progress in medicinal chemistry has been made through the development and
application of imidazole and benzimidazole derivatives. These compounds play a crucial …
application of imidazole and benzimidazole derivatives. These compounds play a crucial …
A medicinal chemist's perspective towards structure activity relationship of heterocycle based anticancer agents
Aim: This paper aims to describe the structure activity relationship of heterocyclic derivatives
with multi-targeted anticancer activity. Objectives: With the following goals in mind, this …
with multi-targeted anticancer activity. Objectives: With the following goals in mind, this …
3D-QSAR modeling and molecular docking studies on a series of 2, 4, 5-trisubstituted imidazole derivatives as CK2 inhibitors
A Goudzal, A El Aissouq, H El Hamdani… - Journal of …, 2023 - Taylor & Francis
Protein case in kinase II alpha subunit (CK2) plays an imperative function in treating cancer
disease. Herein, we have performed a three-dimensional quantitative structure activity …
disease. Herein, we have performed a three-dimensional quantitative structure activity …