Lipotoxicity and diabetic nephropathy: novel mechanistic insights and therapeutic opportunities

L Opazo-Ríos, S Mas, G Marín-Royo… - International journal of …, 2020 - mdpi.com
Lipotoxicity is characterized by the ectopic accumulation of lipids in organs different from
adipose tissue. Lipotoxicity is mainly associated with dysfunctional signaling and insulin …

CHARMM-GUI Membrane Builder: Past, Current, and Future Developments and Applications

S Feng, S Park, YK Choi, W Im - Journal of chemical theory and …, 2023 - ACS Publications
Molecular dynamics simulations of membranes and membrane proteins serve as
computational microscopes, revealing coordinated events at the membrane interface. As G …

[HTML][HTML] Cholesterol and matrisome pathways dysregulated in astrocytes and microglia

TCW Julia, L Qian, NH Pipalia, MJ Chao, SA Liang… - Cell, 2022 - cell.com
The impact of apolipoprotein E ε4 (APOE4), the strongest genetic risk factor for Alzheimer's
disease (AD), on human brain cellular function remains unclear. Here, we investigated the …

Sustained miRNA delivery from an injectable hydrogel promotes cardiomyocyte proliferation and functional regeneration after ischaemic injury

LL Wang, Y Liu, JJ Chung, T Wang, AC Gaffey… - Nature biomedical …, 2017 - nature.com
MicroRNA-based therapies that target cardiomyocyte proliferation have great potential for
the treatment of myocardial infarction. In previous work, we showed that the miR-302/367 …

Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling

G Luchetti, R Sircar, JH Kong, S Nachtergaele… - Elife, 2016 - elifesciences.org
Cholesterol is necessary for the function of many G-protein coupled receptors (GPCRs). We
find that cholesterol is not just necessary but also sufficient to activate signaling by the …

GsMTx4: mechanism of inhibiting mechanosensitive ion channels

R Gnanasambandam, C Ghatak, A Yasmann… - Biophysical journal, 2017 - cell.com
GsMTx4 is a spider venom peptide that inhibits cationic mechanosensitive channels (MSCs).
It has six lysine residues that have been proposed to affect membrane binding. We …

Cholesterol depletion using methyl-β-cyclodextrin

S Mahammad, I Parmryd - Methods in membrane lipids, 2015 - Springer
Cholesterol is an essential component of mammalian cells. It is the major lipid constituent of
the plasma membrane and is also abundant in most other organelle membranes. In the …

Disruption of membrane cholesterol organization impairs the activity of PIEZO1 channel clusters

P Ridone, E Pandzic, M Vassalli, CD Cox… - Journal of General …, 2020 - rupress.org
The human mechanosensitive ion channel PIEZO1 is gated by membrane tension and
regulates essential biological processes such as vascular development and erythrocyte …

[HTML][HTML] Sustained gene delivery from inflammation-responsive anti-inflammatory hydrogels promotes extracellular matrix metabolism balance in degenerative …

Y Wang, M Deng, Y Wu, C Hu, B Zhang, C Guo… - Composites Part B …, 2022 - Elsevier
The progression of intervertebral disc degeneration (IDD) is characterized by an initial
chronic local inflammatory response and ultimately leads to unbalanced anabolic/catabolic …

Affinity-driven design of cargo-switching nanoparticles to leverage a cholesterol-rich microenvironment for atherosclerosis therapy

H Kim, S Kumar, DW Kang, H Jo, JH Park - ACS nano, 2020 - ACS Publications
Atherosclerotic plaques exhibit high deposition of cholesterol and macrophages. These are
not only the main components of the plaques but also key inflammation-triggering sources …