The cytokine TNF is a critical mediator of immune and inflammatory responses. The TNF
gene is an immediate early gene, rapidly transcribed in a variety of cell types following …

Recent advances in cancer immunotherapy have clearly shown that checkpoint-based
immunotherapy is effective in a small subgroup of cancer patients. However, no effective …

We report a high-quality draft of the genome sequence of the grey, short-tailed opossum
(Monodelphis domestica). As the first metatherian ('marsupial') species to be sequenced, the …

The major histocompatibility complex (MHC) is a large genetic region with many genes,
including the highly polymorphic classical class I and II genes that play crucial roles in …

To investigate the role of apoM in high density lipoprotein (HDL) metabolism and
atherogenesis, we generated human apoM transgenic (apoM-Tg) and apoM-deficient (apoM …

In mammals, leptin and tumor-necrosis factor (TNF) are prominent interacting adipokines
mediating appetite control and insulin sensitivity. While TNF pleiotropically functions in …

Upon emerging from the ribosome exiting tunnel, polypeptide folding occurs immediately
with the assistance of both ribosome‐associated and free chaperones. While many …

Noncanonical exon usage plays many important roles in cellular phenotypes, but its
contribution to human B-cell development remains sketchily understood. To fill this gap, we …

Variation within the non-coding genome may influence the regulation and expression of
important genes involved in immune control such as the human leukocyte antigen (HLA) …

All life must survive their corresponding viruses. Thus antiviral systems are essential in all
living organisms. Remnants of virus derived information are also found in all life forms but …