Protein–protein interactions (PPIs) execute many fundamental cellular functions and have
served as prime drug targets over the last two decades. Interfering intracellular PPIs with …

The presence of cell and tissue barriers together with the low biomembrane permeability of
various therapeutics often hampers systemic drug distribution; thus, most of the available …

Patients with Coronavirus disease 2019 exhibit low expression of interferon-stimulated
genes, contributing to a limited antiviral response. Uncovering the underlying mechanism of …

The accumulation of irreparable cellular damage restricts healthspan after acute stress or
natural aging. Senescent cells are thought to impair tissue function, and their genetic …

The c-Jun N-terminal kinases (JNKs), as members of the mitogen-activated protein kinase
(MAPK) family, mediate eukaryotic cell responses to a wide range of abiotic and biotic stress …

Excitotoxicity is classically defined as the neuronal damage caused by the excessive
release of glutamate, and subsequent activation of excitatory plasma membrane receptors …

Abstract NMDA (N-methyl-d-aspartate) receptors (NMDARs) play a central role in excitotoxic
neuronal death caused by ischemic stroke, but NMDAR channel blockers have failed to be …

Excitotoxicity, the specific type of neurotoxicity mediated by glutamate, may be the missing
link between ischemia and neuronal death, and intervening the mechanistic steps that lead …

c-Jun N-terminal kinases (JNKs) are a family of protein kinases that play a central role in
stress signaling pathways implicated in gene expression, neuronal plasticity, regeneration …

Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) family
members function in a cell context-specific and cell type-specific manner to integrate signals …