Inherited ichthyoses are a group of genetic disorders characterized by generalized dry skin,
scaling and hyperkeratosis, and often associated with erythroderma. These manifestations …

Abstract Ubiquitin Proteasome System (UPS) is an adaptable and finely tuned system that
sustains proteostasis network under a large variety of physiopathological conditions. Its …

The proteasome processes proteins to facilitate immune recognition and host defense.
When inherently defective, it can lead to aberrant immunity resulting in a dysregulated …

Disrupted antiviral immune responses are associated with severe COVID-19, the disease
caused by SAR-CoV-2. Here, we show that the 73-amino-acid protein encoded by ORF9c of …

Inherited monogenic palmoplantar keratodermas are a heterogeneous group of conditions
characterised by persistent epidermal thickening of the palmoplantar skin. Palmoplantar …

Inborn errors of immunity (IEI) or primary immune deficiencies (PIDD) are caused by variants
in genes encoding for molecules that are relevant to the innate or adaptive immune …

Different cellular processes that contribute to protein production in Chinese hamster ovary
(CHO) cells have been previously investigated by proteomics. However, although the …

Yellow catfish (Pelteobagrus fulvidraco) is one of the most important economic freshwater
species in China. However, infection by bacterial pathogenic diseases has caused high …

The proteasome is involved in the regulation of all cellular pathways and consequently plays
a central role in the control of cellular homeostasis. Together with its regulators, it is at the …

Keratosis linearis with ichthyosis congenita and sclerosing keratoderma (KLICK) syndrome
is a rare autosomal recessive skin disorder characterized by palmoplantar keratoderma …