Curcumin: Biological activities and modern pharmaceutical forms
M Urošević, L Nikolić, I Gajić, V Nikolić, A Dinić… - Antibiotics, 2022 - mdpi.com
Curcumin (1, 7-bis-(4-hydroxy-3-methoxyphenyl)-hepta-1, 6-diene-3, 5-dione) is a natural
lipophilic polyphenol that exhibits significant pharmacological effects in vitro and in vivo …
lipophilic polyphenol that exhibits significant pharmacological effects in vitro and in vivo …
Bile reflux and hypopharyngeal cancer
Laryngopharyngeal reflux, a variant of gastroesophageal reflux disease, has been
considered a risk factor in the development of hypopharyngeal cancer. Bile acids are …
considered a risk factor in the development of hypopharyngeal cancer. Bile acids are …
[HTML][HTML] Effect of curcumin on attenuation of liver cirrhosis via genes/proteins and pathways: A system pharmacology study
Background: Liver cirrhosis is a life-threatening seqsuel of many chronic liver disorders of
varying etiologies. In this study, we investigated protein targets of curcumin in liver cirrhosis …
varying etiologies. In this study, we investigated protein targets of curcumin in liver cirrhosis …
Weakly acidic bile is a risk factor for hypopharyngeal carcinogenesis evidenced by DNA damage, antiapoptotic function, and premalignant dysplastic lesions in vivo
Simple Summary The etiologic role of biliary reflux in hypopharyngeal cancer is supported
by clinical data. Although, reflux episodes often occur at pH 4.0, they can also occur at …
by clinical data. Although, reflux episodes often occur at pH 4.0, they can also occur at …
Pepsin promotes activation of epidermal growth factor receptor and downstream oncogenic pathways, at slightly acidic and neutral pH, in exposed hypopharyngeal …
Pepsin refluxate is considered a risk factor for laryngopharyngeal carcinogenesis. Non-
acidic pepsin was previously linked to an inflammatory and tumorigenic effect on …
acidic pepsin was previously linked to an inflammatory and tumorigenic effect on …
Sorafenib alleviates inflammatory signaling of tumor microenvironment in precancerous lung injuries
According to population-based studies, lung cancer is the prominent reason for cancer-
related mortality worldwide in males and is also rising in females at an alarming rate …
related mortality worldwide in males and is also rising in females at an alarming rate …
Noxious Combination of Tobacco Smoke Nitrosamines with Bile, Deoxycholic Acid, Promotes Hypopharyngeal Squamous Cell Carcinoma, via NFκB, In Vivo
Tobacco smoking is the most known risk factor for hypopharyngeal cancer. Bile reflux has
recently been documented as an independent risk factor for NFκB-mediated …
recently been documented as an independent risk factor for NFκB-mediated …
[HTML][HTML] Role of curcumin in selected head and neck lesions. Limitations on the use of the Hep-2 cell line: A critical review
L Piwowarczyk, M Stawny, K Piwowarczyk… - Biomedicine & …, 2022 - Elsevier
Neoplastic diseases of the upper respiratory airways, as well as head and neck cancers, are
a frequent cause of death and significantly affect the quality of life of both patients and …
a frequent cause of death and significantly affect the quality of life of both patients and …
A novel saliva and serum miRNA panel as a potential useful index for oral cancer and the association of miR-21 with smoking history: a pilot study
Tobacco use is implicated in the carcinogenesis of oral squamous cell carcinoma (OSCC),
which is associated with poor survival if not diagnosed early. Identification of novel …
which is associated with poor survival if not diagnosed early. Identification of novel …
Targeting STAT3 prevents bile reflux‐induced oncogenic molecular events linked to hypopharyngeal carcinogenesis
The signal transducer and activator of transcription 3 (STAT3) oncogene is a transcription
factor with a central role in head and neck cancer. Hypopharyngeal cells (HCs) exposed to …
factor with a central role in head and neck cancer. Hypopharyngeal cells (HCs) exposed to …