Genetic interactions identify combinations of genetic variants that impinge on phenotype.
With whole-genome sequence information available for thousands of individuals within a …

Highlights•Compound target ID technologies have unique strengths that can be used
strategically.•Target ID approaches are trending toward unbiased, genome-wide …

INTRODUCTION Genetic interactions occur when mutations in two or more genes combine
to generate an unexpected phenotype. An extreme negative or synthetic lethal genetic …

Genome-wide phenotypic screens in the budding yeast Saccharomyces cerevisiae, enabled
by its knockout collection, have produced the largest, richest, and most systematic …

The lack of disease-modifying treatments for neurodegenerative disease stems in part from
our rudimentary understanding of disease mechanisms and the paucity of targets for …

Large-scale biological networks represent relationships between genes, but our
understanding of how networks are functionally organized is limited. Here, I describe spatial …

Members of the diazeniumdiolate class of natural compounds show potential for drug
development because of their antifungal, antibacterial, antiviral, and antitumor activities. Yet …

Understanding how microbial pathogens adapt to treatments, humans and clinical
environments is key to infer mechanisms of virulence, transmission and drug resistance …

Fungi and antifungal compounds are relevant to the United Nation's Sustainable
Development Goals. However, the modes‐of‐action of antifungals—whether they are …

High-throughput screening (HTS) is an integral part of early drug discovery. Herein, we
focused on those small molecules in a screening collection that have never shown …