Mitochondria as a therapeutic target for common pathologies

MP Murphy, RC Hartley - Nature Reviews Drug Discovery, 2018 - nature.com
Although the development of mitochondrial therapies has largely focused on diseases
caused by mutations in mitochondrial DNA or in nuclear genes encoding mitochondrial …

Design and challenges of radiopharmaceuticals

K Vermeulen, M Vandamme, G Bormans… - Seminars in nuclear …, 2019 - Elsevier
This review describes general concepts with regard to radiopharmaceuticals for diagnostic
or therapeutic applications that help to understand the specific challenges encountered …

Mitochondrial damage induced by T-2 mycotoxin on human skin—fibroblast Hs68 cell line

E Janik-Karpinska, M Ceremuga, M Niemcewicz… - Molecules, 2023 - mdpi.com
T-2 toxin is produced by different Fusarium species and belongs to the group of type A
trichothecene mycotoxins. T-2 toxin contaminates various grains, such as wheat, barley …

Quantitative PET in the 2020s: a roadmap

SR Meikle, V Sossi, E Roncali, SR Cherry… - Physics in medicine …, 2021 - iopscience.iop.org
Positron emission tomography (PET) plays an increasingly important role in research and
clinical applications, catalysed by remarkable technical advances and a growing …

[HTML][HTML] Mitochondrial dynamics mediated by DRP1 and MFN2 contributes to cisplatin chemoresistance in human ovarian cancer SKOV3 cells

GP Zou, CX Yu, SL Shi, QG Li, XH Wang, XH Qu… - Journal of …, 2021 - ncbi.nlm.nih.gov
Cisplatin (DDP) is the first-line chemotherapeutic agent for ovarian cancer. However, the
development of DDP resistance seriously influences the chemotherapeutic effect and …

Mitochondrial energetics with transmembrane electrostatically localized protons: do we have a thermotrophic feature?

JW Lee - Scientific Reports, 2021 - nature.com
Transmembrane electrostatically localized protons (TELP) theory has been recently
recognized as an important addition over the classic Mitchell's chemiosmosis; thus, the …

Cardio-oncology: understanding the intersections between cardiac metabolism and cancer biology

A Karlstaedt, M Barrett, R Hu, ST Gammons… - Basic to Translational …, 2021 - jacc.org
An important priority in the cardiovascular care of oncology patients is to reduce morbidity
and mortality, and improve the quality of life in cancer survivors through cross-disciplinary …

Common methods in mitochondrial research

Y Yin, H Shen - International Journal of Molecular …, 2022 - spandidos-publications.com
Mitochondrial abnormalities are primarily seen in morphology, structure and function. They
can cause damage to organs, including the heart, brain and muscle, by various …

PET imaging of mitochondrial function in acute doxorubicin-induced cardiotoxicity: a proof-of-principle study

FJ Detmer, NM Alpert, SH Moon, M Dhaynaut… - Scientific Reports, 2022 - nature.com
Mitochondrial dysfunction plays a key role in doxorubicin-induced cardiotoxicity (DIC). In this
proof-of-principle study, we investigated whether PET mapping of cardiac membrane …

How and when to measure mitochondrial inner membrane potentials

AJ Kowaltowski, F Abdulkader - Biophysical Journal, 2024 - cell.com
The scientific literature on mitochondria has increased significantly over the years, due to
findings that these organelles have widespread roles in the onset and progression of …