BK polyomavirus nephropathy in kidney transplantation: balancing rejection and infection

CL Shen, BS Wu, TJ Lien, AH Yang, CY Yang - Viruses, 2021 - mdpi.com
BK polyomavirus nephropathy (BKVN) and allograft rejection are two closely-associated
diseases on opposite ends of the immune scale in kidney transplant recipients. The principle …

BK polyomavirus infection and nephropathy: the virus–immune system interplay

N Babel, HD Volk, P Reinke - Nature Reviews Nephrology, 2011 - nature.com
Reactivation of latent BK polyomavirus (BKV) infection continues to be a major challenge in
renal graft recipients. Progression of BKV infection to BKV-associated nephropathy (BKVAN) …

[HTML][HTML] BK polyomavirus in solid organ transplantation

HH Hirsch, P Randhawa… - American journal of …, 2013 - Elsevier
The human BK polyomavirus (BKV) is the major cause of polyomavirus-associated
nephropathy (PyVAN) putting 1–15% of kidney transplant patients at risk of premature …

Activity of broad-spectrum T cells as treatment for AdV, EBV, CMV, BKV, and HHV6 infections after HSCT

A Papadopoulou, U Gerdemann, UL Katari… - Science translational …, 2014 - science.org
It remains difficult to treat the multiplicity of distinct viral infections that afflict
immunocompromised patients. Adoptive transfer of virus-specific T cells (VSTs) can be safe …

[HTML][HTML] Polyomavirus BK replication in de novo kidney transplant patients receiving tacrolimus or cyclosporine: a prospective, randomized, multicenter study

HH Hirsch, F Vincenti, S Friman, M Tuncer… - American journal of …, 2013 - Elsevier
Polyomavirus BK (BKV)-associated nephropathy causes premature kidney transplant (KT)
failure. BKV viruria and viremia are biomarkers of disease progression, but associated risk …

[HTML][HTML] BK virus in solid organ transplant recipients

HH Hirsch, P Randhawa… - American Journal of …, 2009 - Elsevier
The human polyomavirus BK (BKV) is linked to two major complications in transplant
recipients, polyomavirus-associated nephropathy (PyVAN)(1, 2, 3, 4) and polyomavirus …

[HTML][HTML] BK virus-specific immunity kinetics: a predictor of recovery from polyomavirus BK-associated nephropathy

T Schachtner, K Müller, M Stein, C Diezemann… - American Journal of …, 2011 - Elsevier
Impaired BKV-specific immunity is associated with development of BKV-associated
nephropathy. Suitable immunological parameters to identify patients at risk, however, are …

[HTML][HTML] Pathology of resolving polyomavirus-associated nephropathy

T Menter, M Mayr, S Schaub, MJ Mihatsch… - American journal of …, 2013 - Elsevier
Control of polyomavirus BK (BKV) is achieved by reducing immunosuppression allowing an
effective BKV-specific T-cell response. The morphology of resolving BKV-associated …

[HTML][HTML] The loss of BKV-specific immunity from pretransplantation to posttransplantation identifies kidney transplant recipients at increased risk of BKV replication

T Schachtner, M Stein, N Babel, P Reinke - American Journal of …, 2015 - Elsevier
Quantification of BKV-load and BKV-specific immunity have been evaluated to monitor BKV-
replication and outcomes in kidney transplant recipients (KTRs) with BKV-infection …

The immunology of SARS-CoV-2 infection and vaccines in solid organ transplant recipients

D Dęborska-Materkowska, D Kamińska - Viruses, 2021 - mdpi.com
Since its outbreak in December 2019, the coronavirus disease 2019 (COVID-19) pandemic,
caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), led to an …