Leishmania, the causative agent of leishmaniases, is an intracellular parasite of
macrophages, transmitted to humans via the bite of its sand fly vector. This protozoan …

The soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) protein
family is of vital importance for organelle communication. The complexing of cognate …

Colonization of host phagocytic cells by Leishmania metacyclic promastigotes involves
several parasite effectors, including the zinc-dependent metalloprotease GP63. The major …

The retrograde transport inhibitor Retro-2 has a protective effect on cells and in mice against
Shiga-like toxins and ricin. Retro-2 causes toxin accumulation in early endosomes and …

The soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE)
syntaxin 5 (Stx5) in mammals and its ortholog Sed5p in Saccharomyces cerevisiae mediate …

The trypanosomatid (protozoan) parasites Trypanosoma cruzi and Leishmania spp. are
causative agents of Chagas disease and Leishmaniasis, respectively. They display high …

The Retro-2 molecule protects cells against Shiga toxins by specifically blocking retrograde
transport from early endosomes to the trans-Golgi network. A SAR study has been carried …

Leishmania spp., transmitted to humans by the bite of the sandfly vector, are responsible for
the three major forms of leishmaniasis, cutaneous, diffuse mucocutaneous and visceral …

The Leishmania parasitophorous vacuole membrane (LPVM) sits at the interface of the
parasite and its host. Evidence shows that molecules from the endocytic pathway as well as …

Cysteine peptidases play a central role in the biology of Leishmania. In this work, we sought
to further elucidate the mechanism (s) by which the cysteine peptidase CPB contributes to L …