Single‐cell RNA sequencing technologies and applications: A brief overview
D Jovic, X Liang, H Zeng, L Lin, F Xu… - Clinical and …, 2022 - Wiley Online Library
Single‐cell RNA sequencing (scRNA‐seq) technology has become the state‐of‐the‐art
approach for unravelling the heterogeneity and complexity of RNA transcripts within …
approach for unravelling the heterogeneity and complexity of RNA transcripts within …
Tutorial: guidelines for the computational analysis of single-cell RNA sequencing data
Single-cell RNA sequencing (scRNA-seq) is a popular and powerful technology that allows
you to profile the whole transcriptome of a large number of individual cells. However, the …
you to profile the whole transcriptome of a large number of individual cells. However, the …
Single-cell transcriptomic characterization of a gastrulating human embryo
RCV Tyser, E Mahammadov, S Nakanoh, L Vallier… - Nature, 2021 - nature.com
Gastrulation is the fundamental process in all multicellular animals through which the basic
body plan is first laid down,,–. It is pivotal in generating cellular diversity coordinated with …
body plan is first laid down,,–. It is pivotal in generating cellular diversity coordinated with …
Symmetric inheritance of parental histones governs epigenome maintenance and embryonic stem cell identity
Modified parental histones are segregated symmetrically to daughter DNA strands during
replication and can be inherited through mitosis. How this may sustain the epigenome and …
replication and can be inherited through mitosis. How this may sustain the epigenome and …
[HTML][HTML] Single-cell RNA sequencing reveals a pro-invasive cancer-associated fibroblast subgroup associated with poor clinical outcomes in patients with gastric …
X Li, Z Sun, G Peng, Y Xiao, J Guo, B Wu, X Li… - Theranostics, 2022 - ncbi.nlm.nih.gov
Background: The protumor activities of cancer-associated fibroblasts (CAFs) suggest that
they are potential therapeutic targets for the treatment of cancer. The mechanism of CAF …
they are potential therapeutic targets for the treatment of cancer. The mechanism of CAF …
Modelling human blastocysts by reprogramming fibroblasts into iBlastoids
Human pluripotent and trophoblast stem cells have been essential alternatives to
blastocysts for understanding early human development 1, 2, 3, 4. However, these simple …
blastocysts for understanding early human development 1, 2, 3, 4. However, these simple …
Single-cell analysis reveals transcriptomic remodellings in distinct cell types that contribute to human prostate cancer progression
Prostate cancer shows remarkable clinical heterogeneity, which manifests in spatial and
clonal genomic diversity. By contrast, the transcriptomic heterogeneity of prostate tumours is …
clonal genomic diversity. By contrast, the transcriptomic heterogeneity of prostate tumours is …
Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis
We provide a single-cell atlas of idiopathic pulmonary fibrosis (IPF), a fatal interstitial lung
disease, by profiling 312,928 cells from 32 IPF, 28 smoker and nonsmoker controls, and 18 …
disease, by profiling 312,928 cells from 32 IPF, 28 smoker and nonsmoker controls, and 18 …
The neutrotime transcriptional signature defines a single continuum of neutrophils across biological compartments
Neutrophils are implicated in multiple homeostatic and pathological processes, but whether
functional diversity requires discrete neutrophil subsets is not known. Here, we apply single …
functional diversity requires discrete neutrophil subsets is not known. Here, we apply single …
Transcriptional signature in microglia associated with Aβ plaque phagocytosis
The role of microglia cells in Alzheimer's disease (AD) is well recognized, however their
molecular and functional diversity remain unclear. Here, we isolated amyloid plaque …
molecular and functional diversity remain unclear. Here, we isolated amyloid plaque …