Ubiquitylation and sumoylation, the covalent attachment of the polypeptides ubiquitin and
SUMO, respectively, to target proteins, are pervasive mechanisms for controlling cellular …

Smc5 and Smc6, together with the kleisin Nse4, form the heart of the enigmatic and poorly
understood Smc5/6 complex, which is frequently viewed as a cousin of cohesin and …

Loss of function of the phosphatase and tensin homolog deleted on chromosome 10 (PTEN)
tumor suppressor gene is associated with many human cancers. In the cytoplasm, PTEN …

Structural maintenance of chromosomes (SMC) complexes, which in eukaryotic cells include
cohesin, condensin and the Smc5/6 complex, are central regulators of chromosome …

Protein modification by SUMO helps orchestrate the elaborate events of meiosis to faithfully
produce haploid gametes. To date, only a handful of meiotic SUMO targets have been …

Eukaryotic SMC complexes, cohesin, condensin, and Smc5/6, use ATP hydrolysis to power
a plethora of functions requiring organization and restructuring of eukaryotic chromosomes …

Faithful transmission of genetic material is crucial for all organisms since changes in genetic
information may result in genomic instability that causes developmental disorders and …

Cohesin facilitates sister chromatid cohesion through the formation of a large ring structure
that encircles DNA. Its function relies on two structural maintenance of chromosomes (Smc) …

Cytoplasmic incompatibility (CI) is a conditional sterility induced by the bacterium Wolbachia
pipientis that infects reproductive tissues in many arthropods. Although CI provides a …

Studies on budding yeast have exposed the highly conserved mechanisms by which
duplicated chromosomes are evenly distributed to daughter cells at the metaphase …