The incidence of neurodegenerative disease like Parkinson's disease and Alzheimer's
disease (AD) increases dramatically with age; only a small percentage is directly related to …

This is the report of the first workshop on Incorporating In Vitro Alternative Methods for
Developmental Neurotoxicity (DNT) Testing into International Hazard and Risk Assessment …

The neurotoxicity of methylmercury (MeHg) is well documented in both humans and
animals. MeHg causes acute and chronic damage to multiple organs, most profoundly the …

An in vitro model, the aggregating brain cell culture of fetal rat telencephalon, has been used
to study the maturation-dependent sensitivity of brain cells to two organophosphorus …

The acute exposure of trimethyltin (TMT) develops clinical syndrome characterized by
amnesia, aggressive behavior, and complex seizures. This neurotoxicant selectively …

Trimethyltin (TMT) is a neurotoxicant known to induce early microglial activation. The
present study was undertaken to investigate the role played by these microglial cells in the …

This study characterizes the role of glial cells in chemically induced neurodegeneration. We
evaluated the effect of trimethyltin, a trisubstituted organotin compound that elicits distinct …

An in vitro model, the aggregating brain cell culture of fetal rat telencephalon, has been used
to investigate the influence of glial cells on the neurotoxicity of two organophosphorus …

Central nervous system degenerative diseases are often characterized by an early, strong
reaction of astrocytes and microglia. Both these cell types can play a double role, protecting …

A three-dimensional cell culture system was used as a model to study the influence of low
levels of mercury in the developing brain. Aggregating cell cultures of fetal rat telencephalon …