Exosomes─ nature's lipid nanoparticles, a rising star in drug delivery and diagnostics

R Tenchov, JM Sasso, X Wang, WS Liaw, CA Chen… - ACS …, 2022 - ACS Publications
Exosomes are a subgroup of nanosized extracellular vesicles enclosed by a lipid bilayer
membrane and secreted by most eukaryotic cells. They represent a route of intercellular …

Challenges and opportunities in exosome research—Perspectives from biology, engineering, and cancer therapy

X Li, AL Corbett, E Taatizadeh, N Tasnim, JP Little… - APL …, 2019 - pubs.aip.org
ABSTRACT Exosomes are small ($30–140 nm) lipid bilayer-enclosed particles of
endosomal origin. They are a subset of extracellular vesicles (EVs) that are secreted by most …

Single test-based diagnosis of multiple cancer types using Exosome-SERS-AI for early stage cancers

H Shin, BH Choi, O Shim, J Kim, Y Park, SK Cho… - Nature …, 2023 - nature.com
Early cancer detection has significant clinical value, but there remains no single method that
can comprehensively identify multiple types of early-stage cancer. Here, we report the …

Methodological guidelines to study extracellular vesicles

FAW Coumans, AR Brisson, EI Buzas… - Circulation …, 2017 - Am Heart Assoc
Owing to the relationship between extracellular vesicles (EVs) and physiological and
pathological conditions, the interest in EVs is exponentially growing. EVs hold high hopes …

The biology and function of exosomes in cancer

R Kalluri - The Journal of clinical investigation, 2016 - Am Soc Clin Investig
Humans circulate quadrillions of exosomes at all times. Exosomes are a class of
extracellular vesicles released by all cells, with a size range of 40–150 nm and a lipid …

The biology of cancer exosomes: insights and new perspectives

CF Ruivo, B Adem, M Silva, SA Melo - Cancer research, 2017 - AACR
Exosomes are a subclass of extracellular vesicles involved in intercellular communication
that are released by all cell types, including cancer cells. Cancer exosomes carry malignant …

Tumor innervation: peripheral nerves take control of the tumor microenvironment

SM Gysler, R Drapkin - The Journal of clinical investigation, 2021 - Am Soc Clin Investig
In recent decades, cancer research has expanded exponentially beyond the study of
abnormally dividing cells to include complex and extensive heterotypic interactions between …

The microRNA regulatory landscape of MSC-derived exosomes: a systems view

SW Ferguson, J Wang, CJ Lee, M Liu… - Scientific reports, 2018 - nature.com
Mesenchymal stem cell (MSC)-derived exosomes mediate tissue regeneration in a variety of
diseases including ischemic heart injury, liver fibrosis, and cerebrovascular disease. Despite …

[HTML][HTML] Blockade of exosome generation with GW4869 dampens the sepsis-induced inflammation and cardiac dysfunction

K Essandoh, L Yang, X Wang, W Huang, D Qin… - … et Biophysica Acta (BBA …, 2015 - Elsevier
Sepsis is an infection-induced severe inflammatory disorder that leads to multiple organ
failure. Amongst organs affected, myocardial depression is believed to be a major …

Exosomal miR-223 contributes to mesenchymal stem cell-elicited cardioprotection in polymicrobial sepsis

X Wang, H Gu, D Qin, L Yang, W Huang, K Essandoh… - Scientific reports, 2015 - nature.com
Mesenchymal stem cells (MSCs) have been shown to elicit cardio-protective effects in
sepsis. However, the underlying mechanism remains obscure. While recent studies have …