Cancer is a complex disease in which several molecular and cellular pathways converge to
foster the tumoral phenotype. Notably, in the latest iteration of the cancer hallmarks,“ …

The perturbation of DNA replication, a phenomena termed “replication stress”, is a driving
force of genome instability and a hallmark of cancer cells. Among the DNA repair …

Timely repair of chromosomal double-strand breaks is required for genome integrity and
cellular viability. The polymerase theta-mediated end joining pathway has an important role …

Synthetic lethality is a genetic phenomenon whereby the simultaneous presence of two
different genetic alterations impairs cellular viability. Importantly, targeting synthetic lethal …

Since their discovery in the late 20 th century, significant progress has been made in
elucidating the functions of the tumor suppressor proteins BRCA1 and BRCA2. These …

Common fragile sites (CFS) are specific genomic regions prone to chromosomal instability
under conditions of DNA replication stress. CFSs manifest as breaks, gaps, and constrictions …

DNA is a remarkable biochemical macromolecule tasked with storing the genetic information
that instructs life on planet Earth. However, its inherent chemical instability within the cellular …

Replication stress is a major contributor to tumorigenesis because it provides a source of
chromosomal rearrangements via recombination events. PARK2, which encodes parkin, a …

Homologous recombination deficiency (HRD) is considered a universal and effective sign of
a tumor's sensitivity to poly (ADP-ribose) polymerase (PARP) inhibitors. HRD diagnostics …

BRCA1 and BRCA2 play a central role in DNA repair and their germline pathogenic variants
(g BRCA) confer a high risk for developing breast and ovarian cancer. Standard …