The discovery of new compounds with antitumoral activity has become one of the most
important goals in medicinal chemistry. One interesting group of chemotherapeutic agents …

Approximately 40% of the world population live in areas with the risk of malaria. Each year,
300–500 million people suffer from acute malaria, and 0.5–2.5 million die from the disease …

Sida acuta is a shrub indigenous to pantropical regions. The plant is widely used for its
various pharmacological properties. Among compounds of pharmacological interest …

Introduction: Despite concerns about toxicity, potentially harmful effects and herb-drug
interactions, the use of herbal medicines remains widely practiced by people living with …

The dynamics of biological processes depend on the structure and flexibility of the
interacting molecules. In particular, the conformational diversity of DNA allows for large …

Several aspects of the intercalation of organic dyes into DNA are presented. After a
description of general features of intercalation and the analytical evaluation of this binding …

As the carrier of genetic information, the DNA double helix interacts with many natural
ligands during the cell cycle, and is amenable to such intervention in diseases such as …

Model systems have been studied using density functional theory to assess the contributions
of π-resonance and through-space effects on electrostatic potentials (ESPs) of substituted …

Background The discovery and development of new anti-malarials are at a crossroads.
Fixed dose artemisinin combination therapy is now being used to treat a hundred million …

Traditional medicines have contributed greatly over the centuries to the discovery and
development of new therapeutic agents and indoloquinoline alkaloids may represent a new …