It has been known for more than 60 years, and suspected for over 100, that alveolar hypoxia
causes pulmonary vasoconstriction by means of mechanisms local to the lung. For the last …

The properties and roles of ATP-sensitive (KATP) and inwardly rectifying (KIR) potassium
channels are reviewed. Potassium channels regulate the membrane potential of smooth …

This review discusses recent advances in the understanding of the ways in which different
organs detect and respond to acute changes in oxygen tension. A group of specialized …

▪ Abstract O2 sensing is a fundamental biological process necessary for adaptation of living
organisms to variable habitats and physiological situations. Cellular responses to hypoxia …

Hypoxia initiates pulmonary vasoconstriction (HPV) by inhibiting one or more voltage-gated
potassium channels (Kv) in the pulmonary artery smooth muscle cells (PASMCs) of …

Hypoxia causes constriction in small pulmonary arteries and dilatation in systemic arteries.
Hypoxic pulmonary vasoconstriction (HPV) is an important mechanism by which pulmonary …

Hypoxic pulmonary vasoconstriction (HPV), also known as the von Euler–Liljestrand
mechanism, is an essential response of the pulmonary vasculature to acute and sustained …

The effector mechanism of hypoxic pulmonary vasoconstriction (HPV) involves K+ channel
inhibition with subsequent membrane depolarization. It remains uncertain how hypoxia …

Pulmonary arterial hypertension (PAH) is a severe and progressive disease that usually
culminates in right heart failure and death if left untreated. Although there have been …

A. Cyclic nucleotides 112 B. Phosphoinoside hydrolysis ii3 C. Protein kinases 113 D.
Calcium channels 113 E. Potassium channels ii4 VII. Pulmonary vasodilators as therapy 114 …