For several years, a great effort has been devoted to understand how circadian oscillations
in physiological processes are determined by the circadian clock system. This system is …

The circadian clock regulates many key physiological processes such as the sleep–wake
cycle, hormone release, cardiovascular health, glucose metabolism and body temperature …

Background Substance use disorders are associated with disruptions in circadian rhythms.
Both human and animal work have shown the integral role for circadian clocks in the …

Retinal photoreceptors undergo daily renewal of their distal outer segments, a process
indispensable for maintaining retinal health. Photoreceptor outer segment (POS) …

Serpinc1 is a serine protease inhibitor in the coagulation cascade, but its role in tumor
biology remains obscure. Here, we report an unexpected role of serpinc1 in suppression of …

For brain protection, the blood–brain barrier and blood–cerebrospinal fluid barrier limit the
traffic of molecules between blood and brain tissue and between blood and cerebrospinal …

Circadian rhythms influence the transport function of the blood–brain barrier (BBB) and
peripheral organs. However, the influence of circadian rhythms on protein expression in the …

Background Tumors exhibit metabolic heterogeneity, influencing cancer progression.
However, understanding metabolic diversity in retinoblastoma (RB), the primary intraocular …

Background Neovascular eye disease is characterized by pathological neovascularization,
with clinical manifestations such as intraocular exudation, bleeding, and scar formation …

The retinal pigment epithelium (RPE) ensures different functions crucial for photoreceptor
survival, and thus for vision, such as photoreceptor outer segments (POS) phagocytosis and …