A systematic review of the valproic-acid-induced rodent model of autism

D Chaliha, M Albrecht, M Vaccarezza… - Developmental …, 2020 - karger.com
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterised by
repetitive behaviours, cognitive rigidity/inflexibility, and social-affective impairment …

Three decades of valproate: a current model for studying autism Spectrum disorder

D Zarate-Lopez, AL Torres-Chávez… - Current …, 2024 - benthamdirect.com
Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder with increased
prevalence and incidence in recent decades. Its etiology remains largely unclear, but it …

Autism spectrum disorder: signaling pathways and prospective therapeutic targets

J Baranova, G Dragunas, MCS Botellho… - Cellular and molecular …, 2021 - Springer
Abstract The Autism Spectrum Disorder (ASD) consists of a prevalent and heterogeneous
group of neurodevelopmental diseases representing a severe burden to affected individuals …

[HTML][HTML] P2 receptor-mediated signaling in the physiological and pathological brain: From development to aging and disease

P Mut-Arbona, B Sperlágh - Neuropharmacology, 2023 - Elsevier
The purinergic pathway mediates both pro-inflammatory and anti-inflammatory responses,
whereas the breakdown of adenosine triphosphate (ATP) is in a critical equilibrium. Under …

Alterations of purinergic receptors levels and their involvement in the glial cell morphology in a pre-clinical model of autism spectrum disorders

L Babiec, A Wilkaniec, M Matuszewska, E Pałasz… - Brain Sciences, 2023 - mdpi.com
Recent data suggest that defects in purinergic signalling are a common denominator of
autism spectrum disorders (ASDs), though nothing is known about whether the disorder …

[HTML][HTML] Metabolic and behavioral features of acute hyperpurinergia and the maternal immune activation mouse model of autism spectrum disorder

Z Zolkipli-Cunningham, JC Naviaux, T Nakayama… - PloS one, 2021 - journals.plos.org
Since 2012, studies in mice, rats, and humans have suggested that abnormalities in
purinergic signaling may be a final common pathway for many genetic and environmental …

Cilostazol attenuated prenatal valproic acid-induced behavioural and biochemical deficits in a rat model of autism spectrum disorder

K Luhach, GT Kulkarni, VP Singh… - Journal of Pharmacy …, 2021 - academic.oup.com
Objectives Autism spectrum disorder (ASD) is categorized as a neurodevelopmental
disorder, presenting with a variety of aetiological and phenotypical features. Inhibiting the …

Adolescent swimming exercise following maternal valproic acid treatment improves cognition and reduces stress-related symptoms in offspring mice: Role of sex and …

A Barzegari, HA Mahdirejei, M Hanani… - Physiology & …, 2023 - Elsevier
Valproic acid (VPA) treatment during pregnancy is a risk factor for developing autism
spectrum disorder, cognitive deficits, and stress-related disorders in children. No effective …

Effects of varied‑intensity endurance exercise training on oxidative and antioxidant factors in the liver of rats with valproic acid‑induced autism

F Mirzavandi, N Sabet, A Aminzadeh, M Heidari… - Acta Neurobiologiae …, 2023 - ane.pl
Autism spectrum disorders are complex behavioral disorders that can be caused by
exposure to valproic acid (VPA) during pregnancy. A therapeutic role for exercise training …

GABAergic synaptic transmission and cortical oscillation patterns in the primary somatosensory area of a valproic acid rat model of autism spectrum disorder

M Fontes‐Dutra, J Righes Marafiga… - European Journal of …, 2023 - Wiley Online Library
Autism spectrum disorder (ASD) is characterized by impaired social communication and
interaction associated with repetitive or stereotyped behaviour. Prenatal valproic acid (VPA) …