Polyunsaturated fatty acids and their metabolites in brain function and disease

RP Bazinet, S Layé - Nature reviews neuroscience, 2014 - nature.com
The brain is highly enriched with fatty acids. These include the polyunsaturated fatty acids
(PUFAs) arachidonic acid and docosahexaenoic acid, which are largely esterified to the …

[HTML][HTML] The importance of marine omega-3s for brain development and the prevention and treatment of behavior, mood, and other brain disorders

JJ DiNicolantonio, JH O'Keefe - Nutrients, 2020 - mdpi.com
Most of the global population is deficient in long-chain marine omega-3s. In particular,
docosahexaenoic acid (DHA), a long-chain omega-3 fatty acid, is important for brain and …

Position of the academy of nutrition and dietetics: dietary fatty acids for healthy adults

G Vannice, H Rasmussen - Journal of the Academy of Nutrition and …, 2014 - Elsevier
It is the position of the Academy of Nutrition and Dietetics (the Academy) that dietary fat for
the healthy adult population should provide 20% to 35% of energy, with an increased …

Food for mood: relevance of nutritional omega-3 fatty acids for depression and anxiety

T Larrieu, S Layé - Frontiers in physiology, 2018 - frontiersin.org
The central nervous system (CNS) has the highest concentration of lipids in the organism
after adipose tissue. Among these lipids, the brain is particularly enriched with …

Meta-analysis of the effects of eicosapentaenoic acid (EPA) in clinical trials in depression

ME Sublette, SP Ellis, AL Geant… - The Journal of clinical …, 2011 - psychiatrist.com
Objective: Randomized trials of omega-3 polyunsaturated fatty acid (PUFA) treatment for
depression have differed in outcome. Recent meta-analyses ascribe discrepancies to …

Association of use of omega-3 polyunsaturated fatty acids with changes in severity of anxiety symptoms: a systematic review and meta-analysis

KP Su, PT Tseng, PY Lin, R Okubo, TY Chen… - JAMA network …, 2018 - jamanetwork.com
Importance No systematic review or meta-analysis has assessed the efficacy of omega-3
polyunsaturated fatty acids (PUFAs) for anxiety. Objective To evaluate the association of …

A meta-analytic review of polyunsaturated fatty acid compositions in patients with depression

PY Lin, SY Huang, KP Su - Biological psychiatry, 2010 - Elsevier
BACKGROUND: On the basis of evidence from studies showing the antidepressant effects of
omega-3 polyunsaturated fatty acids and the inverse relation between fish consumption and …

[HTML][HTML] Is docosahexaenoic acid synthesis from α-linolenic acid sufficient to supply the adult brain?

AF Domenichiello, AP Kitson, RP Bazinet - Progress in lipid research, 2015 - Elsevier
Docosahexaenoic acid (DHA) is important for brain function, and can be obtained directly
from the diet or synthesized in the body from α-linolenic acid (ALA). Debate exists as to …

[HTML][HTML] Brain docosahexaenoic acid uptake and metabolism

RJS Lacombe, R Chouinard-Watkins… - Molecular Aspects of …, 2018 - Elsevier
Docosahexaenoic acid (DHA) is the most abundant n-3 polyunsaturated fatty acid in the
brain where it serves to regulate several important processes and, in addition, serves as a …

Efficacy of omega-3 highly unsaturated fatty acids in the treatment of depression

B Hallahan, T Ryan, JR Hibbeln, IT Murray… - The British Journal of …, 2016 - cambridge.org
BackgroundTrials evaluating efficacy of omega-3 highly unsaturated fatty acids (HUFAs) in
major depressive disorder report discrepant findings. AimsTo establish the reasons …