[HTML][HTML] Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network
Z Vinarov, B Abrahamsson, P Artursson… - Advanced Drug Delivery …, 2021 - Elsevier
Although oral drug delivery is the preferred administration route and has been used for
centuries, modern drug discovery and development pipelines challenge conventional …
centuries, modern drug discovery and development pipelines challenge conventional …
Electrospun Janus core (ethyl cellulose//polyethylene oxide)@ shell (hydroxypropyl methyl cellulose acetate succinate) hybrids for an enhanced colon-targeted …
J Zhou, T Yi, Z Zhang, DG Yu, P Liu, L Wang… - … Composites and Hybrid …, 2023 - Springer
Structural polymeric nanohybrids is presently a popular topic and can be conceived for
numerous functional applications, including the pH-sensitive oral colon-targeted drug …
numerous functional applications, including the pH-sensitive oral colon-targeted drug …
Supersaturation and Precipitation Applicated in Drug Delivery Systems: Development Strategies and Evaluation Approaches
Y Gan, JPA Baak, T Chen, H Ye, W Liao, H Lv, C Wen… - Molecules, 2023 - mdpi.com
Supersaturation is a promising strategy to improve gastrointestinal absorption of poorly
water-soluble drugs. Supersaturation is a metastable state and therefore dissolved drugs …
water-soluble drugs. Supersaturation is a metastable state and therefore dissolved drugs …
Use of physiologically based pharmacokinetic (PBPK) modeling for predicting drug-food interactions: an industry perspective
AE Riedmaier, K DeMent, J Huckle, P Bransford… - The AAPS journal, 2020 - Springer
The effect of food on pharmacokinetic properties of drugs is a commonly observed
occurrence affecting about 40% of orally administered drugs. Within the pharmaceutical …
occurrence affecting about 40% of orally administered drugs. Within the pharmaceutical …
Use of physiologically based pharmacokinetic modeling for predicting drug–food interactions: Recommendations for improving predictive performance of low …
Food can alter drug absorption and impact safety and efficacy. Besides conducting clinical
studies, in vitro approaches such as biorelevant solubility and dissolution testing and in vivo …
studies, in vitro approaches such as biorelevant solubility and dissolution testing and in vivo …
Physiologically based absorption modelling to explore the impact of food and gastric pH changes on the pharmacokinetics of entrectinib
N Parrott, C Stillhart, M Lindenberg, B Wagner… - The AAPS Journal, 2020 - Springer
Entrectinib is a potent and selective tyrosine kinase inhibitor (TKI) of TRKA/B/C, ROS1, and
ALK with both systemic and CNS activities, which has recently received FDA approval for …
ALK with both systemic and CNS activities, which has recently received FDA approval for …
The effect of buffer species on biorelevant dissolution and precipitation assays–Comparison of phosphate and bicarbonate buffer
Biorelevant solubility and dissolution testing is an important tool during pharmaceutical
development, however, solubility experiments performed using biorelevant media often do …
development, however, solubility experiments performed using biorelevant media often do …
[HTML][HTML] Integration of advanced methods and models to study drug absorption and related processes: An UNGAP perspective
CG Wilson, L Aarons, P Augustijns, J Brouwers… - European Journal of …, 2022 - Elsevier
This collection of contributions from the European Network on Understanding
Gastrointestinal Absorption-related Processes (UNGAP) community assembly aims to …
Gastrointestinal Absorption-related Processes (UNGAP) community assembly aims to …
Physiologically based biopharmaceutics model for selumetinib food effect investigation and capsule dissolution safe space–part I: adults
XJH Pepin, M Hammarberg, A Mattinson… - Pharmaceutical …, 2023 - Springer
Objective A physiologically based biopharmaceutics model (PBBM) was developed to
mechanistically investigate the effect of formulation and food on selumetinib …
mechanistically investigate the effect of formulation and food on selumetinib …
Impact of co-administered stabilizers on the biopharmaceutical performance of regorafenib amorphous solid dispersions
M Müller, R Wiedey, W Hoheisel, P Serno… - European Journal of …, 2021 - Elsevier
Poor solubility of drug candidates is a well-known and thoroughly studied challenge in the
development of oral dosage forms. One important approach to tackle this challenge is the …
development of oral dosage forms. One important approach to tackle this challenge is the …