Daily dietary potassium (K+) intake may be as large as the extracellular K+ pool. To avoid
acute hyperkalemia, rapid removal of K+ from the extracellular space is essential. This is …

The NLRP3 inflammasome is a multi-molecular complex that acts as a molecular platform to
mediate caspase-1 activation, leading to IL-1β/IL-18 maturation and release in cells …

Diabetic nephropathy is characterized by damage to both the glomerulus and
tubulointerstitium, but relatively little is known about accompanying cell-specific changes in …

The choroid plexus (ChP) is the blood-cerebrospinal fluid (CSF) barrier and the primary
source of CSF. Acquired hydrocephalus, caused by brain infection or hemorrhage, lacks …

Transmembrane potassium (K) gradients are key determinants of membrane potential that
can modulate action potentials, control muscle contractility, and influence ion channel and …

Growing evidence indicates that oxidative and endoplasmic reticular stress, which trigger
changes in ion channels and inflammatory pathways that may undermine cellular …

Regulated Na+ transport in the distal nephron is of fundamental importance to fluid and
electrolyte homeostasis. Further upstream, Na+ is the principal driver of secondary active …

Taraxasterol (TAS) is an active ingredient of Dandelion (Taraxacum mongolicum Hand.-
Mazz.), a medicinal plant that has long been used in China for treatment of inflammatory …

Mammalian (or mechanistic) target of rapamycin complex 2 (mTORC2) is a kinase complex
that targets predominantly Akt family proteins, SGK1 and protein kinase C (PKC), and has …

Potassium often has a negative connotation in Nephrology as patients with chronic kidney
disease (CKD) are prone to develop hyperkalaemia. Approaches to the management of …