Innate immunity serves as the rapid and first-line defense against invading pathogens, and
this process can be regulated at various levels, including epigenetic mechanisms. The …

Neurodegenerative diseases (NDs) are characteristic with progression of neuron
degeneration, resulting in dysfunction of cognition and mobility. Many neurodegenerative …

Proteins of the bromodomain and extra-terminal (BET) family are epigenetics “readers” and
promising therapeutic targets for cancer and other human diseases. We describe herein a …

Alzheimer's disease (AD) is the leading cause of age-related dementia. Neuropathological
hallmarks of AD include brain deposition of β-amyloid (Aβ) plaques and accumulation of …

With the bromodomain (BRD) inhibitor JQ1, a remarkable success story of BRD4 as a novel
drug target has been set off that yielded many anti‐cancer drugs that are now in clinical …

Basal cell carcinoma (BCC) of the skin is driven by aberrant hedgehog signaling. Thus
blocking this signaling pathway by small molecules such as vismodegib inhibits tumor …

Aging is a significant risk factor for Alzheimer's disease (AD), although the precise
mechanism and molecular basis of AD are not yet fully understood. Epigenetic mechanisms …

Chronic pain, such as persistent inflammatory pain, remains a public health problem that
has no effective treatment at present. Bromodomain-containing protein 4 (BRD4) inhibition …

Progressive supranuclear palsy (PSP) is an incurable neurodegenerative disease
characterized by 4-repeat (0N/4R)-Tau protein accumulation in CNS neurons. We generated …

The dynamic changes in chromatin conformation alter the organization and structure of the
genome and further regulate gene transcription. Basically, the chromatin structure is …