While significant progress has been made in terms of human immunodeficiency virus (HIV)
therapy, treatment does not represent a cure and remains inaccessible to many people …

The nucleolus is a multifunctional nuclear domain primarily dedicated to ribosome
biogenesis. Certain viruses developed strategies to manipulate host nucleolar proteins to …

Background RNA interference is a gene regulatory mechanism that employs small RNA
molecules such as microRNA. Previous work has shown that HIV-1 produces TAR viral …

Approximately 8% of the human genome is made up of endogenous retroviral sequences.
As the HIV-1 Tat protein activates the overall expression of the human endogenous …

The trans-activator Tat protein is a viral regulatory protein essential for HIV-1 replication. Tat
trafficks to the nucleoplasm and the nucleolus. The nucleolus, a highly dynamic and …

Relatively little is known at the functional genomic level about the global host response to
human immunodeficiency virus type 1 (HIV-1) infection. Microarray analyses by several …

HIV-1 latency generates reservoirs that prevent viral eradication by the current therapies. To
find strategies toward an HIV cure, detailed understandings of the molecular mechanisms …

The human immunodeficiency virus type 1 (HIV-1) regulator Tat is essential for viral
replication because it achieves complete elongation of viral transcripts. Tat can be released …

HIV-1 replication is efficiently controlled by the regulator protein Tat (101 amino acids) and
codified by two exons, although the first exon (1–72 amino acids) is sufficient for this …

We previously demonstrated that replication-competent adenovirus (Ad)-simian
immunodeficiency virus (SIV) recombinant prime/protein boost regimens elicit potent …