Abstract The epithelial Na+ channel (ENaC) transports Na+ across tight epithelia, including
the distal nephron. Different paradigms of ENaC regulation include extrinsic and intrinsic …

In utero, fetal lung epithelial cells actively secrete Cl− ions into the lung air spaces while Na+
ions follow passively to maintain electroneutrality. This process, driven by an …

The epithelial Na+ channel (ENaC) is a pathway for Na+ transport across epithelia,
including the kidney collecting duct, lung, and distal colon. ENaC is critical for Na+ …

The steroid hormone aldosterone stimulates sodium (Na+) transport in tight epithelia by
altering the expression of target genes that regulate the activity and trafficking of the …

The steroid hormone aldosterone is important for salt and water homeostasis as well as for
pathological tissue modifications in the cardiovascular system and the kidney. The …

We recently found that the metabolic sensor AMP-activated kinase (AMPK) inhibits the
epithelial Na+ channel (ENaC) through decreased plasma membrane ENaC expression, an …

The mineralocorticoid receptor (MR) belongs to the steroid hormone receptor family and
classically functions as a ligand-dependent transcription factor. It is involved in water …

The epithelial Na+ channel (ENaC) regulates epithelial salt and water reabsorption,
processes that require significant expenditure of cellular energy. To test whether the …

Lipocalin 2, an iron-siderophore-binding protein, converts embryonic kidney mesenchyme to
epithelia. We found that lipocalin 2 could also convert 4T1-Ras-transformed mesenchymal …

Inflammation, although necessary to fight infections, becomes a threat when it exceeds the
capability of the immune system to control it. In addition, inflammation is a cause and/or …