[HTML][HTML] Lipid alterations in chronic liver disease and liver cancer

B Paul, M Lewinska, JB Andersen - JHEP reports, 2022 - Elsevier
Lipids are a complex and diverse group of molecules with crucial roles in many
physiological processes, as well as in the onset, progression, and maintenance of cancers …

[HTML][HTML] Alcohol consumption and metabolic syndrome: clinical and epidemiological impact on liver disease

F Åberg, CD Byrne, CJ Pirola, V Männistö… - Journal of …, 2023 - Elsevier
Alcohol use and metabolic syndrome are highly prevalent in the population and frequently
co-exist. Both are implicated in a large range of health problems, including chronic liver …

The intersection between alcohol-related liver disease and nonalcoholic fatty liver disease

LA Díaz, JP Arab, A Louvet, R Bataller… - Nature Reviews …, 2023 - nature.com
Nonalcoholic fatty liver disease (NAFLD) and alcohol-related liver disease (ALD) are the
leading causes of chronic liver disease worldwide. NAFLD and ALD share …

[HTML][HTML] Recent advances towards mass spectrometry-based clinical lipidomics

S Salihovic, S Lamichane, T Hyötyläinen… - Current opinion in …, 2023 - Elsevier
The objective of this review is to provide a comprehensive summary of the latest
methodological advancements and emerging patterns in utilizing lipidomics in clinical …

[HTML][HTML] Atorvastatin for patients with cirrhosis. A randomized, placebo-controlled trial

TM Kronborg, R Schierwagen, K Trošt… - Hepatology …, 2023 - journals.lww.com
Background: Patients with cirrhosis and portal hypertension face a high risk of
complications. Besides their anti-inflammatory and antifibrotic effects, statins may reduce …

Binge drinking episode causes acute, specific alterations in systemic and hepatic inflammation‐related markers

E Stankevic, M Israelsen, HB Juel, AL Madsen… - Liver …, 2023 - Wiley Online Library
Background Frequent binge drinking is a known contributor to alcohol‐related harm, but its
impact on systemic and hepatic inflammation is not fully understood. We hypothesize that …

Utility of human relevant preclinical animal models in navigating NAFLD to MAFLD paradigm

D Chua, ZS Low, GX Cheam, AS Ng… - International Journal of …, 2022 - mdpi.com
Fatty liver disease is an emerging contributor to disease burden worldwide. The past
decades of work established the heterogeneous nature of non-alcoholic fatty liver disease …

Metabolic signature of ethanol-induced hepatotoxicity in HepaRG cells by liquid chromatography–mass spectrometry-based untargeted metabolomics

E Iturrospe, KM da Silva, R Robeyns… - Journal of proteome …, 2022 - ACS Publications
Alcoholic liver disease is highly prevalent but poorly identified and characterized, leading to
knowledge gaps, which impairs early diagnosis. Excessive alcohol consumption is known to …

Waist-hip ratio is superior to BMI in predicting liver-related outcomes and synergizes with harmful alcohol use

F Åberg, M Färkkilä, V Salomaa, A Jula… - Communications …, 2023 - nature.com
Background: Obesity is associated with liver disease, but the best obesity-related predictor
remains undefined. Controversy exists regarding possible synergism between obesity and …

Bioactive signaling lipids as drivers of chronic liver diseases

E Kaffe, A Tisi, C Magkrioti, V Aidinis, WZ Mehal… - Journal of …, 2023 - Elsevier
Lipids are important components for multiple cellular functions, and most have structural or
energy storage roles. However, a small fraction of lipids exerts bioactive roles through …