Human adenoviruses are the most widely used vectors in gene medicine, with applications
ranging from oncolytic therapies to vaccinations, but adenovirus vectors are not without side …

The conserved, multifunctional Polymerase-Associated Factor 1 complex (Paf1C) regulates
all stages of the RNA polymerase (Pol) II transcription cycle. In this review, we examine a …

Monoubiquitylation of histone H2B (H2Bub1), catalyzed by the heterodimeric ubiquitin
ligase complex RNF20/40, regulates multiple molecular and biological processes. The …

In the 1990s, adenovirus became one of the first virus types to be genetically engineered to
selectively destroy cancer cells. In the intervening years, the field of “oncolytic viruses” has …

Adenoviruses are one of the most genetically diverse DNA viruses and cause non-
lifethreatening infections in the ocular, respiratory, or gastrointestinal epithelium of a diverse …

As obligate intracellular parasites, viruses are dependent on their infected hosts for survival.
Consequently, viruses are under enormous selective pressure to utilize available cellular …

Interferons (IFNs) are cytokines that have pleiotropic effects and play important roles in
innate and adaptive immunity. IFNs have broad antiviral properties and function by different …

Kaposi's sarcoma-associated herpesvirus (KSHV) is an oncogenic DNA virus whose lytic
replication cycle is induced and driven by the viral transcription factor RTA (replication and …

The Adenovirus (Ad) genome within the capsid is tightly associated with a virus-encoded,
histone-like core protein—protein VII. Two other Ad core proteins, V and X/μ, also are …

Viruses alter host cell processes to optimize their replication cycle. Human adenoviruses
(Ad) encode proteins that promote viral macromolecular synthesis and counteract innate …