The family of gasdermin proteins plays a key role in the host response against external and
internal pathogenic signals by mediating the form of inflammatory regulated cell death …

Many systemically administered cancer therapies exhibit dose-limiting toxicities that reduce
their effectiveness. To increase efficacy, bacterial delivery platforms have been developed …

The gut microbiota prevents harmful microbes from entering the body, a function known as
colonization resistance. The enteric pathogen Salmonella enterica serovar (S.) Typhimurium …

Immune cells must be able to adjust their metabolic programs to effectively carry out their
effector functions. Here, we show that the endoplasmic reticulum (ER) stress sensor Inositol …

The type III secretion system encoded in the Salmonella pathogenicity island-2 (SPI-2) gene
cluster facilitates intracellular growth of nontyphoidal Salmonella by interfering with the …

Salmonella enterica is the leading cause of bacterial foodborne illness in the USA, with an
estimated 95% of salmonellosis cases due to the consumption of contaminated food …

Salmonella enterica serovar Enteritidis is a common foodborne pathogen that infects both
humans and animals. The S. Enteritidis virulence regulation network remains largely …

Brucella spp. are facultatively intracellular bacteria that can infect, survive, and multiply in
various host cell types in vivo and/or in vitro. The genus Brucella has markedly expanded in …

Numerous bacterial pathogens “confine” themselves within host cells with an intracellular
localization as main or exclusive niche. Many of them switch dynamically between a …

The intestinal epithelium is the first line of defense against enteric pathogens. Removal of
infected cells by exfoliation prevents mucosal translocation and systemic infection in the …