The cellular events that lead to terminal erythroid differentiation rely on the controlled
interplay of extra-and intracellular regulatory factors. Their downstream effects are highly …

This review focuses on structure and functions of spectrin as a major component of the
membrane skeleton. Recent advances on spectrin function as an interface for signal …

The abLIM1 is a nonerythroid actin-binding protein critical for stable plasma membrane–
cortex interactions under mechanical tension. Its depletion by RNA interference results in …

Coordination of cellular processes through the establishment of tissue-specific gene
expression programs is essential for lineage maturation. The basic helix-loop-helix …

Erythroid Kruppel-like factor (EKLF, KLF1) plays an important role in definitive erythropoiesis
and β-globin gene regulation but failure to rectify lethal fetal anemia upon correction of …

The spectrin-based membrane skeleton is a ubiquitous membrane-associated two-
dimensional cytoskeleton underneath the lipid membrane of metazoan cells. Mutations of …

Development of red blood cells requires the correct regulation of cellular processes
including changes in cell morphology, globin expression and heme synthesis. Transcription …

Krüppel-like factor 1 (KLF1) plays a crucial role in erythropoiesis. In-depth studies conducted
on mice and humans have highlighted its importance in erythroid lineage commitment …

Red blood cell (RBC)-derived systems offer a potential platform for delivery of biomedical
cargos. Although the importance of specific proteins associated with the biodistribution and …

To date, it has been shown that the phenomenon of liquid–liquid phase separation (LLPS)
underlies many seemingly completely different cellular processes. This provided a new idea …