Each day, approximately 50 to 70 billion cells perish in the average adult because of
programmed cell death (PCD). Cell death in self-renewing tissues, such as the skin, gut, and …

Obesity is associated with an increased risk of breast cancer in postmenopausal women.
Accumulating evidence suggests that adipose tissue, which is an endocrine organ …

DNA Ligase IV is responsible for sealing of double-strand breaks (DSBs) during
nonhomologous end-joining (NHEJ). Inhibiting Ligase IV could result in amassing of DSBs …

We investigated the mRNA expression levels of all six antiapoptotic Bcl-2 subfamily
members in 68 human cancer cell lines using qPCR techniques and measured the ability of …

Abstract The phosphoinositide-3-kinase (PI3K)/Akt signaling pathway plays an important
role in cell survival and the development of cancer. Macrophage migration inhibitory factor …

Constitutive nuclear nuclear factor (NF)-κB activity is observed in a variety of hematopoietic
and solid tumors. Given the distinctive role of constitutive NF-κB for Hodgkin and Reed …

With the goal of identifying key factors involved in human breast cancer progression, we
applied human cytokine antibody arrays we have developed to screen cytokine expression …

Purpose: Doxorubicin is administrated as a single agent in first-line therapy of breast cancer
to induce apoptosis in tumor cells. Bax, Bcl-xL, Caspase-8 and 9 proteins are involved in …

To the Editor: Chemoprevention can prevent second primary cancers in patients with cancer,
1 but the effect of secondary cancer prevention on absolute survival has not been …

Many anticancer strategies rely on the promotion of apoptosis in cancer cells as a means to
shrink tumors. Crucial for apoptotic function are executioner caspases, most notably …