There is mounting urgency to find new drugs for the treatment of serious infectious diseases
and cancer that are rapidly developing resistance to previously effective drugs. One …

Malaria inflicts an enormous burden on global human health. The emergence of parasite
resistance to front-line drugs has prompted a renewed focus on the repositioning of clinically …

The prevention and treatment of malaria is heavily dependent on antimalarial drugs.
However, beginning with the emergence of chloroquine (CQ)-resistant Plasmodium …

Lymphatic filariasis and onchocerciasis are debilitating diseases caused by parasitic filarial
nematodes infecting around 150 million people throughout the tropics with more than 1.5 …

Africa, Asia, and Latin America are regions highly affected by endemic diseases, such as
Leishmaniasis, Malaria, and Chagas' disease. They are responsible for the death of 1000s …

Human cytochrome P-450 (CYP-450), family 2, subfamily A, polypeptide 6 (CYP2A6) is a
monooxygenase enzyme that metabolizes xenobiotic compounds and activates toxins [1–3] …

Background Treatment and morbidity control of schistosomiasis relies on a single drug,
praziquantel. Hence, there is a pressing need to develop additional therapeutics against …

Background Resistances to currently available drugs and insecticides, significant drug
toxicities and costs and lack of vaccines currently complicated the treatment of malaria. A …

Malaria continues to be an important public health problem in the world. Nowadays, the
widespread parasite resistance to many drugs used in antimalarial therapy has made the …

Malaria is a devastating parasitic disease which caused around 216 million cases and
445,000 deaths worldwide in 2016. This might be attributed to a wide spread of drug …