Our understanding of neuroendocrine prostate cancer (NEPC) has assumed a new
perspective in light of the recent advances in research. Although classical NEPC is rarely …

The signal transducer and activator of transcription (STAT) 3 governs essential functions of
epithelial and hematopoietic cells that are often dysregulated in cancer. While the role for …

N-myc-downregulated gene 1 (NDRG1) has potent anticancer effects and inhibits cell
growth, survival, metastasis, and angiogenesis. Previous studies suggested that NDRG1 is …

STAT3 is the most ubiquitous member of the STAT family and involved in many biological
processes, such as cell proliferation, differentiation, and apoptosis. Mounting evidence has …

Abstract Neuroendocrine/Aggressive Variant Prostate Cancers are lethal variants of the
disease, with an aggressive clinical course and very short responses to conventional …

BACKGROUND Paracrine interleukin‐6 (IL‐6) can mediate neuroendocrine (NE) features,
including the acquisition of a neurite‐like phenotype and growth arrest in prostate cancer …

Suppressors of cytokine signalling 1–7 (SOCS1–7) and cytokine‐inducible SH2‐containing
protein (CIS) are a group of intracellular proteins that are well known as JAK‐STAT and …

Simple Summary The suppressors of cytokine signaling (SOCS) are known cytokine-
inducible negative regulators of JAK/STAT and other cell signaling pathways. Deregulation …

Prostate cancer (PC) is the most frequently diagnosed cancer and the second leading cause
of cancer-related death in men in the Western society. Unfortunately, although the vast …

Castration-resistant prostate cancer (CRPC) has become a significant problem in the current
treatment of prostate cancer (PCa) with the characteristics of high metastatic potential …