The blood–brain barrier: structure, regulation, and drug delivery
Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous
system (CNS) from toxins and pathogens in blood. However, the presence of BBB …
system (CNS) from toxins and pathogens in blood. However, the presence of BBB …
Multidrug resistance in cancer: understanding molecular mechanisms, immunoprevention and therapeutic approaches
Cancer is one of the leading causes of death worldwide. Several treatments are available for
cancer treatment, but many treatment methods are ineffective against multidrug-resistant …
cancer treatment, but many treatment methods are ineffective against multidrug-resistant …
[HTML][HTML] Environmental antibiotics and resistance genes as emerging contaminants: methods of detection and bioremediation
In developing countries, the use of antibiotics has helped to reduce the mortality rate by
minimizing the deaths caused by pathogenic infections, but the costs of antibiotic …
minimizing the deaths caused by pathogenic infections, but the costs of antibiotic …
What is known about breast cancer in young women?
Simple Summary Breast cancer is the most common cancer affecting women under 40 years
of age worldwide, with an increasing number of cases diagnosed each year. Despite this …
of age worldwide, with an increasing number of cases diagnosed each year. Despite this …
Core–shell-type lipid–polymer hybrid nanoparticles as a drug delivery platform
B Mandal, H Bhattacharjee, N Mittal, H Sah… - … , Biology and Medicine, 2013 - Elsevier
The focus of nanoparticle design over the years has evolved toward more complex
nanoscopic core–shell architecture using a single delivery system to combine multiple …
nanoscopic core–shell architecture using a single delivery system to combine multiple …
Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs
AH Schinkel, JJM Smit, O van Tellingen, JH Beijnen… - Cell, 1994 - cell.com
We have generated mice homozygous for a disruption of the mdrfa (also called mdr3) gene,
encoding a drugtransporting P-glycoprotein. The mice were viable and fertile and appeared …
encoding a drugtransporting P-glycoprotein. The mice were viable and fertile and appeared …
Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease
JJM Smit, AH Schinkel, RPJO Elferink, AK Groen… - Cell, 1993 - cell.com
Two types of P-glycoprotein have been found in mammals: the drug-transporting P-
glycoproteins and a second type, unable to transport hydrophobic anticancer drugs. The …
glycoproteins and a second type, unable to transport hydrophobic anticancer drugs. The …
P-Glycoprotein, a gatekeeper in the blood–brain barrier
AH Schinkel - Advanced drug delivery reviews, 1999 - Elsevier
The blood–brain barrier is a major impediment to the entry of many therapeutic drugs into
the brain. P-Glycoprotein is an ATP-dependent drug transport protein that is predominantly …
the brain. P-Glycoprotein is an ATP-dependent drug transport protein that is predominantly …
Proton-dependent multidrug efflux systems
IT Paulsen, MH Brown, RA Skurray - Microbiological reviews, 1996 - Am Soc Microbiol
Multidrug efflux systems display the ability to transport a variety of structurally unrelated
drugs from a cell and consequently are capable of conferring resistance to a diverse range …
drugs from a cell and consequently are capable of conferring resistance to a diverse range …
Structure-based strategies for drug design and discovery
ID Kuntz - Science, 1992 - science.org
Most drugs have been discovered in random screens or by exploiting information about
macromolecular receptors. One source of this information is in the structures of critical …
macromolecular receptors. One source of this information is in the structures of critical …