Antitumor therapeutic strategies that fundamentally rely on the induction of DNA damage to
eradicate and inhibit the growth of cancer cells are integral approaches to cancer therapy …

DNA damage response (DDR) pathway prevents high level endogenous and environmental
DNA damage being replicated and passed on to the next generation of cells via an …

Cancer stem cells are enriched in triple‑negative breast cancer (TNBC) tumor tissues, which
present strong capacities of proliferation and tumorigenicity. The present study detected the …

Impaired DNA repair drives mutagenicity, which increases neoantigen load and
immunogenicity. We investigated the expression of proteins involved in the DNA damage …

Oncogene-induced senescence (OIS) or apoptosis through the DNA-damage response is
an important barrier of tumorigenesis. Overcoming this barrier leads to abnormal cell …

Lung cancer is the leading cause of cancer-related mortality in the USA and worldwide, and
of the estimated 1.2 million new cases of lung cancer diagnosed every year, over 30% are …

The ATM gene is mutated in the syndrome, ataxia-telangiectasia (AT), which is
characterized by predisposition to cancer. Patients with AT have an elevated risk of breast …

Introduction The moderate-penetrance germline mutations ATM, CHEK2, and PALB2 are
implicated in an increased risk of the development of breast cancer. Whether these …

Radiation-induced DNA damage activates the DNA damage response (DDR). DDR up-
regulation may predict radio-resistance and increase the risk of early local recurrence …

RECQL5 is a member of the RecQ family of DNA helicases and has key roles in
homologous recombination, base excision repair, replication and transcription. The …