Hypertrophic scars and keloids: advances in treatment and review of established therapies

FS Frech, L Hernandez, R Urbonas, GA Zaken… - American journal of …, 2023 - Springer
Hypertrophic scars and keloids can have significant detrimental effects on patients both
psychosocially and functionally. A careful identification of patient risk factors and a …

Keloid treatments: an evidence-based systematic review of recent advances

LA Walsh, E Wu, D Pontes, KR Kwan, S Poondru… - Systematic reviews, 2023 - Springer
Background Keloids are pathologic scars that pose a significant functional and cosmetic
burden. They are challenging to treat, despite the multitude of treatment modalities currently …

Optimizing radiotherapy for keloids: a meta-analysis systematic review comparing recurrence rates between different radiation modalities

P Mankowski, J Kanevsky, J Tomlinson… - Annals of plastic …, 2017 - journals.lww.com
Background The high recurrence rate of keloids has lead to the use of multiple treatment
adjuncts to improve cosmetic outcomes after surgery. To date, there has been no single …

Surgical excision with adjuvant irradiation for treatment of keloid scars: a systematic review

MCE van Leeuwen, SC Stokmans… - … Surgery–Global Open, 2015 - journals.lww.com
Background: Excision followed by adjuvant irradiation is considered safe and most
efficacious for treatment of keloid scars. Recently, different authors published successful …

Comparison of surgical excision followed by adjuvant radiotherapy and laser combined with steroids for the treatment of keloids: A systematic review and meta …

S Fu, L Duan, Y Zhong, Y Zeng - International Wound Journal, 2024 - Wiley Online Library
This meta‐analysis aims to evaluate and compare the effect of surgical excision followed by
adjuvant radiotherapy and laser combined with steroids on keloids. Relevant studies …

Fibrosis in burns: an overview of mechanisms and therapies

S Faour, M Farahat, A Aijaz… - American Journal of …, 2023 - journals.physiology.org
Scar development remains a common occurrence and a major healthcare challenge
affecting the lives of millions of patients annually. Severe injuries to the skin, such as burns …

Mesenchymal stem cell therapy in hypertrophic and keloid scars

C Bojanic, K To, A Hatoum, J Shea, KTM Seah… - Cell and Tissue …, 2021 - Springer
Scars are the normal outcome of wound repair and involve a co-ordinated inflammatory and
fibrotic process. When a scar does not resolve, uncontrolled chronic inflammation can …

Radiation therapy modalities for keloid management: a critical review

EK Liu, RF Cohen, ES Chiu - Journal of Plastic, Reconstructive & Aesthetic …, 2022 - Elsevier
Objective To provide a critical overview of current radiation modalities for keloid
management. Background Despite multimodal therapies, keloids that can develop following …

Radiation therapy in keloids treatment: history, strategy, effectiveness, and complication

J Xu, E Yang, NZ Yu, X Long - Chinese medical journal, 2017 - journals.lww.com
Objective: Radiation therapy combined with surgical excision was considered as one of the
most effective treatment plans for keloid lesions. However, there was no unanimity found …

Assessing keloid recurrence following surgical excision and radiation

MH Gold, MS Nestor, B Berman, D Goldberg - Burns & Trauma, 2020 - academic.oup.com
Keloids are a fibroproliferative disorder that can result from a cutaneous injury to the reticular
dermis. Recurrence rates as high as 100% have been reported following surgical excision …