Pathogen persistence in the respiratory tract is an important preoccupation, and of particular
relevance to infectious diseases such as tuberculosis. The equilibrium between elimination …

Lipid droplets (LDs) are cellular organelles comprising a core of neutral lipids (glycerides,
sterols) encased within a single phospholipid membrane, responsible for storing surplus …

Tuberculosis, caused by the intracellular pathogen Mycobacterium tuberculosis, remains the
world's deadliest infectious disease. Sterilizing chemotherapy requires at least 6 months of …

Tuberculosis (TB) is a leading cause of death worldwide following infection with
Mycobacterium tuberculosis (Mtb), with 1.5 million deaths from this disease reported in …

Tuberculosis (TB) is one of the oldest human diseases and is one of the major causes of
mortality and morbidity across the Globe. Mycobacterium tuberculosis (Mtb), the causal …

Mycobacterium tuberculosis infects primarily macrophages in the lungs. Infected
macrophages are surrounded by other immune cells in well organised structures called …

The ability of Mycobacterium tuberculosis to cause disease hinges upon successfully
thwarting the innate defenses of the macrophage host cell. The pathogen's trump card is its …

CRISPR interference (CRISPRi) and CRISPR activation (CRISPRa) have become
ubiquitous approaches to control gene expression in bacteria due to their simple design and …

Intracellular pathogens including Mycobacterium tuberculosis (Mtb) have evolved with
strategies to uptake amino acids from host cells to fulfil their metabolic requirements …

Macrophages act as immune scavengers and are important cell types in the homeostasis of
various tissues. Given the multiple roles of macrophages, these cells can also be found as …