The CRISPR-Cas system is commonly known for its ability to cleave DNA in a
programmable manner, which has democratized gene editing and facilitated recent …

Mammalian cells can acquire exogenous amino acids through endocytosis and lysosomal
catabolism of extracellular proteins. In amino acid-replete environments, nutritional …

Protein–protein interactions (PPIs) orchestrate nearly all biological processes. They are also
considered attractive drug targets for treating many human diseases, including cancers and …

The trans-cleavage activity of Cas12a has been widely used with various applications. Here,
we report that the trans-cleavage activity of Cas12a can be significantly affected by the …

COPII and COPI mediate the formation of membrane vesicles translocating in opposite
directions within the secretory pathway. Live-cell and electron microscopy revealed a novel …

Translocon clogging at the endoplasmic reticulum (ER) as a result of translation stalling
triggers ribosome UFMylation, activating translocation-associated quality control (TAQC) to …

Mutations in DNAJC5/CSPα are associated with adult neuronal ceroid lipofuscinosis
(ANCL), a dominant-inherited neurodegenerative disease featuring lysosome-derived …

The changes occurring in mRNA organization during nucleo-cytoplasmic transport and
export, are not well understood. Moreover, directionality of mRNA passage through the …

Nuclear envelope herniations (blebs) containing FG-nucleoporins and ubiquitin are the
phenotypic hallmark of Torsin ATPase manipulation. Both the dynamics of blebbing and the …

Abstract AGPATs (1-acylglycerol-3-phosphate O-acyltransferases) catalyze the acylation of
lysophosphatidic acid to form phosphatidic acid (PA), a key step in the glycerol-3-phosphate …