Radiation oncology in the era of precision medicine

M Baumann, M Krause, J Overgaard, J Debus… - Nature Reviews …, 2016 - nature.com
Technological advances and clinical research over the past few decades have given
radiation oncologists the capability to personalize treatments for accurate delivery of …

The national centre for oncological hadrontherapy (CNAO): status and perspectives

S Rossi - Physica Medica, 2015 - Elsevier
Abstract The National Centre for Oncological Hadrontherapy (CNAO, sited in Pavia, Italy)
completed at the end of 2013 the clinical trial phase achieving the CE label from the notified …

The CNAO dose delivery system for modulated scanning ion beam radiotherapy

S Giordanengo, MA Garella, F Marchetto… - Medical …, 2015 - Wiley Online Library
Purpose: This paper describes the system for the dose delivery currently used at the Centro
Nazionale di Adroterapia Oncologica (CNAO) for ion beam modulated scanning …

Particle therapy of moving targets—the strategies for tumour motion monitoring and moving targets irradiation

T Kubiak - The British Journal of Radiology, 2016 - academic.oup.com
Particle therapy of moving targets is still a great challenge. The motion of organs situated in
the thorax and abdomen strongly affects the precision of proton and carbon ion …

Online image guided tumour tracking with scanned proton beams: a comprehensive simulation study

Y Zhang, A Knopf, C Tanner… - Physics in Medicine & …, 2014 - iopscience.iop.org
Tumour tracking with scanned particle beams potentially requires accurate 3D information
on both tumour motion and related density variations. We have previously developed a …

[HTML][HTML] Commissioning and quality assurance of a novel solution for respiratory-gated PBS proton therapy based on optical tracking of surface markers

G Fattori, J Hrbacek, H Regele, C Bula, A Mayor… - … für medizinische Physik, 2022 - Elsevier
We present the commissioning and quality assurance of our clinical protocol for respiratory
gating in pencil beam scanning proton therapy for cancer patients with moving targets. In a …

Evaluation of residual abdominal tumour motion in carbon ion gated treatments through respiratory motion modelling

G Meschini, M Seregni, A Pella, M Ciocca, P Fossati… - Physica Medica, 2017 - Elsevier
Abstract At the Italian National Centre for Oncologic Hadrontherapy (CNAO) patients with
upper-abdominal tumours are being treated with carbon ion therapy, adopting the …

A modular dose delivery system for treating moving targets with scanned ion beams: Performance and safety characteristics, and preliminary tests

M Lis, M Donetti, W Newhauser, M Durante, J Dey… - Physica Medica, 2020 - Elsevier
Purpose The purpose of this study was to develop a modular dose-delivery system (DDS) for
scanned-ion radiotherapy that mitigates against organ motion artifacts by synchronizing the …

Multigating, a 4D optimized beam tracking in scanned ion beam therapy

C Graeff, A Constantinescu… - … in cancer research …, 2014 - journals.sagepub.com
The treatment of moving tumors with a scanned ion beam is challenging due to interplay
effects and changing beam range. We propose multigating, as a method for 4D-treatment …

Spot weight adaptation for moving target in spot scanning proton therapy

P Morel, X Wu, G Blin, S Vialette, R Flynn… - Frontiers in …, 2015 - frontiersin.org
Purpose This study describes a real-time spot weight adaptation method in spot-scanning
proton therapy for moving target or moving patient, so that the resultant dose distribution …