Gene drives may be capable of addressing ecological problems by altering entire
populations of wild organisms, but their use has remained largely theoretical due to …

Human pathogens that are transmitted by insects are a global problem, particularly those
vectored by mosquitoes; for example, malaria parasites transmitted by Anopheles species …

Genetic engineering technologies can be used both to create transgenic mosquitoes
carrying antipathogen effector genes targeting human malaria parasites and to generate …

The huge burden of malaria in developing countries urgently demands the development of
novel approaches to fight this deadly disease. Although engineered symbiotic bacteria have …

Humans have dramatic, diverse and far-reaching influences on the evolution of other
organisms. Numerous examples of this human-induced contemporary evolution have been …

Anopheles gambiae is the principal vector of malaria, a disease that afflicts more than 500
million people and causes more than 1 million deaths each year. Tenfold shotgun sequence …

Site-specific selfish genes exploit host functions to copy themselves into a defined target
DNA sequence, and include homing endonuclease genes, group II introns and some LINE …

During the 1930s and 1940s the idea of releasing insects of pest species to introduce
sterility (sterile insect technique or SIT) into wild populations, and thus control them, was …

A description is given of a fully automatic program, written in ALGOL 60, that finds the
constants of the reciprocal lattice from powder data. The progress of the program is …

Genetic methods of manipulating or eradicating disease vector populations have long been
discussed as an attractive alternative to existing control measures because of their potential …