The 19F isotope is 100% naturally abundant and is the second most sensitive and stable
NMR-active nucleus. Unlike the ubiquitous hydrogen atom, fluorine is nearly absent in …

A variety of nuclear magnetic resonance (NMR) applications have been developed for
structure-based drug discovery (SBDD). NMR provides many advantages over other …

19F NMR has emerged as a powerful tool in drug discovery, particularly in fragment-based
screens. The favorable magnetic resonance properties of the fluorine-19 nucleus, the …

Fluorine is a valuable probe for investigating the interactions of biological molecules
because of its favorable NMR characteristics, its small size, and its near total absence from …

Two radical-based approaches have been developed to effect the trifluoromethylation of aryl
C–H bonds in native peptides either using stoichiometric oxidant or visible light photoredox …

NMR spectroscopy can be used to quantify the binding affinity between proteins and low-
complexity molecules, termed'fragments'; this versatile screening approach allows …

Side chain-fluorinated amino acids are useful tools in medicinal chemistry and protein
science. In this review, we outline some general strategies for incorporating fluorine atom (s) …

The last five years have witnessed major developments in the understanding of the allosteric
phenomenon, broadly defined as coupling between remote molecular sites. Such advances …

We describe a 19F NMR method for detecting bromodomain–ligand interactions using
fluorine-labeled aromatic amino acids due to the conservation of aromatic residues in the …

Dysregulation of transcription is found in nearly every human disease, and as a result there
has been intense interest in developing new therapeutics that target regulators of …