[HTML][HTML] Alzheimer's disease pathophysiology in the retina

BP Gaire, Y Koronyo, DT Fuchs, H Shi… - Progress in Retinal and …, 2024 - Elsevier
The retina is an emerging CNS target for potential noninvasive diagnosis and tracking of
Alzheimer's disease (AD). Studies have identified the pathological hallmarks of AD …

Determinants of approved acetylcholinesterase inhibitor response outcomes in Alzheimer's disease: relevance for precision medicine in neurodegenerative diseases

S Lista, A Vergallo, SJ Teipel, P Lemercier… - Ageing research …, 2023 - Elsevier
Acetylcholinesterase inhibitors (ChEI) are the global standard of care for the symptomatic
treatment of Alzheimer's disease (AD) and show significant positive effects in …

Retinal pathological features and proteome signatures of Alzheimer's disease

Y Koronyo, A Rentsendorj, N Mirzaei, GC Regis… - Acta …, 2023 - Springer
Alzheimer's disease (AD) pathologies were discovered in the accessible neurosensory
retina. However, their exact nature and topographical distribution, particularly in the early …

Identification of retinal oligomeric, citrullinated, and other tau isoforms in early and advanced AD and relations to disease status

H Shi, N Mirzaei, Y Koronyo, MR Davis… - Acta …, 2024 - Springer
This study investigates various pathological tau isoforms in the retina of individuals with
early and advanced Alzheimer's disease (AD), exploring their connection with disease …

Retina pathology as a target for biomarkers for Alzheimer's disease: Current status, ophthalmopathological background, challenges, and future directions

J Alber, F Bouwman, J den Haan… - Alzheimer's & …, 2024 - Wiley Online Library
There is emerging evidence that amyloid beta protein (Aβ) and tau‐related lesions in the
retina are associated with Alzheimer's disease (AD). Aβ and hyperphosphorylated (p)‐tau …

mHealth hyperspectral learning for instantaneous spatiospectral imaging of hemodynamics

Y Ji, SM Park, S Kwon, JW Leem, VV Nair, Y Tong… - PNAS …, 2023 - academic.oup.com
Hyperspectral imaging acquires data in both the spatial and frequency domains to offer
abundant physical or biological information. However, conventional hyperspectral imaging …

Hyperspectral retinal imaging in Alzheimer's disease and age-related macular degeneration: a review

X Du, J Park, R Zhao, RT Smith, Y Koronyo… - Acta Neuropathologica …, 2024 - Springer
While Alzheimer's disease and other neurodegenerative diseases have traditionally been
viewed as brain disorders, there is growing evidence indicating their manifestation in the …

Retinal arterial Aβ40 deposition is linked with tight junction loss and cerebral amyloid angiopathy in MCI and AD patients

H Shi, Y Koronyo, DT Fuchs, J Sheyn… - Alzheimer's & …, 2023 - Wiley Online Library
INTRODUCTION Vascular amyloid beta (Aβ) protein deposits were detected in retinas of
mild cognitively impaired (MCI) and Alzheimer's disease (AD) patients. We tested the …

Potent of strategic approaches for tauopathies ranging from single-cell transcriptome to microbiome

SH Kim, S Yang, E Yang, M Kang… - Animal Cells and …, 2023 - Taylor & Francis
Tauopathies as one of the typical neurodegenerative diseases are characterized by
pathologically aggregated tau in neuron and glia, which causes dysfunction, synapse loss …

Hyperspectral retinal imaging biomarkers of ocular and systemic diseases

A Saeed, X Hadoux, P van Wijngaarden - Eye, 2024 - nature.com
Hyperspectral imaging is a frontier in the field of medical imaging technology. It enables the
simultaneous collection of spectroscopic and spatial data. Structural and physiological …