Understanding the long-term maintenance of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) immunity is critical for predicting protection against reinfection …

Here we report the characterization of 17T2, a SARS-CoV-2 pan-neutralizing human
monoclonal antibody isolated from a COVID-19 convalescent individual infected during the …

Double negative (DN) B cells (CD27-IgD-) comprise a heterogenous population of DN1,
DN2, and the recently described DN3 and DN4 subsets. In autoimmune disease, DN2 cells …

SARS-CoV-2 has infected more than 200 million people worldwide, with more than 4 million
associated deaths. Although more than 80% of infected people develop asymptomatic or …

mRNA-based vaccines effectively induce protective neutralizing antibodies against SARS-
CoV-2, the etiological agent of COVID-19. Yet, the kinetics and compositional patterns of …

Neutralizing antibody is an important indicator of vaccine efficacy, of which IgG is the main
component. IgG can be divided into four subclasses. Up to now, studies analysing the …

Introduction Since December 2019, the emergence of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) causing coronavirus disease 2019 (COVID-19) has presented …

To achieve global herd immunity, widespread vaccination is the most effective strategy.
Vaccines stimulate the immune system, generating cytokines and chemokines, isotype …

The immune status of Coronavirus disease 2019 (COVID-19) patients in different stages of
infection remains difficult to determine. In this study, we performed high-throughput single …

Somatic hypermutation (SHM) is an important diversification mechanism that plays a part in
the creation of immune memory. Immunoglobulin (Ig) variable region gene lineage trees …