The central renin–angiotensin system and sympathetic nerve activity in chronic heart failure

IH Zucker, L Xiao, KKV Haack - Clinical Science, 2014 - portlandpress.com
CHF (chronic heart failure) is a multifactorial disease process that is characterized by
overactivation of the RAAS (renin–angiotensin–aldosterone system) and the sympathetic …

Hypertension, blood pressure variability, and target organ lesion

MC Irigoyen, K De Angelis, F Dos Santos… - Current hypertension …, 2016 - Springer
Hypertensive patients have a higher risk of developing health complications, particularly
cardiovascular (CV) events, than individuals with normal blood pressure (BP). Severity of …

Interstitial-fluid shear stresses induced by vertically oscillating head motion lower blood pressure in hypertensive rats and humans

S Murase, N Sakitani, T Maekawa, D Yoshino… - Nature Biomedical …, 2023 - nature.com
The mechanisms by which physical exercise benefits brain functions are not fully
understood. Here, we show that vertically oscillating head motions mimicking mechanical …

Aerobic exercise reduces oxidative stress and improves vascular changes of small mesenteric and coronary arteries in hypertension

FR Roque, AM Briones… - British journal of …, 2013 - Wiley Online Library
Background and Purpose Regular physical activity is an effective non‐pharmacological
therapy for prevention and control of hypertension. We investigated the effects of aerobic …

Role of proinflammatory cytokines and redox homeostasis in exercise-induced delayed progression of hypertension in spontaneously hypertensive rats

D Agarwal, M Haque, S Sriramula, N Mariappan… - …, 2009 - Am Heart Assoc
Hypertension is a well-known risk factor for various cardiovascular diseases. Recently,
exercise has been recommended as a part of lifestyle modification for all hypertensive …

Preventive role of exercise training in autonomic, hemodynamic, and metabolic parameters in rats under high risk of metabolic syndrome development

IC Moraes-Silva, C Mostarda… - Journal of applied …, 2013 - journals.physiology.org
High fructose consumption contributes to metabolic syndrome incidence, whereas exercise
training promotes several beneficial adaptations. In this study, we demonstrated the …

Impact of exercise training on redox signaling in cardiovascular diseases

JC Campos, KMS Gomes, JCB Ferreira - Food and Chemical Toxicology, 2013 - Elsevier
Reactive oxygen and nitrogen species regulate a wide array of signaling pathways that
governs cardiovascular physiology. However, oxidant stress resulting from disrupted redox …

The benefits of endurance training in cardiomyocyte function in hypertensive rats are reversed within four weeks of detraining

MA Carneiro-Júnior, JF Quintão-Júnior… - Journal of Molecular and …, 2013 - Elsevier
The aim of the present study was to verify the effects of low-intensity endurance training and
detraining on the mechanical and molecular properties of cardiomyocytes from …

Chronic exercise preserves renal structure and hemodynamics in spontaneously hypertensive rats

D Agarwal, CM Elks, SD Reed… - Antioxidants & redox …, 2012 - liebertpub.com
Abstract Aims: Exercise training (ExT) is a recommended adjunct to many pharmaceutical
antihypertensive therapies. The effects of chronic ExT on the development of hypertension …

Up-regulating the heme oxygenase system with hemin improves insulin sensitivity and glucose metabolism in adult spontaneously hypertensive rats

JF Ndisang, N Lane, N Syed, A Jadhav - Endocrinology, 2010 - academic.oup.com
Accumulating clinical evidence indicates that impaired glucose tolerance is a common
phenomenon in essential hypertension. Although recent evidence underscores the role of …