Cyclic guanosine monophosphate (cGMP), an important intracellular second messenger,
mediates cellular functional responses in all vital organs. Phosphodiesterase 5 (PDE5) is …

Cyclic guanosine monophosphate (cGMP), produced by guanylate cyclase (GC), activates
protein kinase G (PKG) and regulates cardiac remodeling. cGMP/PKG signal is activated by …

Sildenafil (SF) is widely used for erectile dysfunction and other conditions, though with
limitations regarding oral absorption and adverse effects. Despite nanotechnological …

Abstract Ethnopharmacological relevance Traditional Chinese medicine theory believes that
qi deficiency and blood stasis are the key pathogenesis of heart failure with preserved …

Phosphodiesterase type 5 (PDE5) is pivotal in cellular signalling, regulating cyclic
guanosine monophosphate (cGMP) levels crucial for smooth muscle relaxation and …

The dose-response relationship of sildenafil effects on cardiac function is not completely
elucidated. The aim of this study was to assess the effects of different doses of sildenafil on …

Aging-related hypoxia, oxidative stress, and inflammation pathophysiology are closely
associated with human age-related carcinogenesis and chronic diseases. However, the …

3′-5′ cyclic nucleotide phosphodiesterases (PDEs) are a family of evolutionarily
conserved cAMP and/or cGMP hydrolyzing enzymes, components of transduction pathways …

Significant surgical and medical advances over the past several decades have resulted in a
growing number of infants and children surviving with hypoplastic left heart syndrome …

磷酸二酯酶5 (PDE5) 是环磷酸鸟苷(cGMP) 特异性水解酶, 是由一氧化氮(NO)
激活的可溶性鸟苷酸环化酶(sGC) 靶向cGMP 产生的. PDE5 催化cGMP 中磷酸二酯键的水解 …