Reactive oxygen species (ROS), superoxide anion and hydrogen peroxide, are generated
as byproducts of oxidative phosphorylation in the mitochondria or via cell signaling-induced …

An appropriate balance between self-renewal and differentiation is crucial for stem cell
function during both early development and tissue homeostasis throughout life. Recent …

In metazoans, the nuclear lamina is thought to play an important role in the spatial
organization of interphase chromosomes, by providing anchoring sites for large genomic …

Long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) represent two classes of
important non-coding RNAs in eukaryotes. Although these non-coding RNAs have been …

Oxidative stress, associated with either normal metabolism or disease conditions, affects
many cellular activities. Most of our knowledge in this field is derived from fully differentiated …

Loss of heterozygosity (LOH) is a common genetic event in the development of cancer. In
certain tumor types, LOH can affect more than 20% of the genome, entailing loss of allelic …

The POU domain family of transcription factors regulates developmental processes ranging
from specification of the early embryo to terminal differentiation. About half of these factors …

Abstract The POU (Pit-Oct-Unc) protein family is an evolutionary ancient group of
transcription factors (TFs) that bind specific DNA sequences to direct gene expression …

It is a classic story of two related transcription factors. Oct4 is a potent regulator of
pluripotency during early mammalian embryonic development, and is notable for its ability to …

Stress is normal during early embryogenesis and transient, elevated stress is commonplace.
Stress in the milieu of the peri-implantation embryo is a summation of maternal hormones …